Dimeric guaianolides from Artemisia absinthium

被引：30

作者：

Turak, Ablajan ^{[1
]}

Shi, She-Po ^{[2
]}

Jiang, Yong ^{[1
]}

Tu, Peng-Fei ^{[1
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Beijing Univ Tradit Chinese Med, Modem Res Ctr Tradit Chinese Med, Beijing 100191, Peoples R China

来源：

PHYTOCHEMISTRY | 2014年 / 105卷

基金：

中国国家自然科学基金;

关键词：

Wormwood; Artemisia absinthium; Asteraceae; Dimeric guaianolides; Single-crystal X-ray analysis; Inhibition of NO production; BV-2; cells; SESQUITERPENE LACTONE;

D O I：

10.1016/j.phytochem.2014.06.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five dimeric guaianolides, absinthins A-E, and seven known dimeric guaianolides were isolated from Artemisia absinthium. Their structures were elucidated based on 1D- and 2D-NMR experiments, including H-1 NMR, C-13 NMR, DEPT, H-1-H-1 COSY, HSQC, HMBC, and NOESY, and through HRESIMS data analysis. The absolute configuration of the known compound, anabsinthin, was determined by X-ray crystallographic analysis. The isolated compounds were tested to assess their inhibitory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 cells; absinthin C and isoanabsinthin exhibited significant inhibitory effects with IC50 values of 1.52 and 1.98 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：109 / 114

页数：6

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