Role of retinoic receptors in lung carcinogenesis

被引：23

作者：

Bogos, Krisztina ^{[1
,2
,3
]}

Renyi-Vamos, Ferenc ^{[1
,3
]}

Kovacs, Gabor ^{[2
,3
]}

Tovari, Jozsef ^{[1
,3
]}

Dome, Balazs ^{[1
,2
,3
]}

机构：

[1] Tumor Biol, Budapest, Hungary

[2] Thorac Oncol Natl Koranyi Inst Pulmonol, Budapest, Hungary

[3] Natl Inst Oncol, Dept Tumor Progress, Budapest, Hungary

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2008年 / 27卷 / 1期

关键词：

D O I：

10.1186/1756-9966-27-18

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several in vitro and in vivo studies have examined the positive and negative effects of retinoids (vitamin A analogs) in premalignant and malignant lesions. Retinoids have been used as chemopreventive and anticancer agents because of their pleiotropic regulator function in cell differentiation, growth, proliferation and apoptosis through interaction with two types of nuclear receptors: retinoic acid receptors and retinoid X receptors. Recent investigations have gradually elucidated the function of retinoids and their signaling pathways and may explain the failure of earlier chemopreventive studies. In this review we have compiled basic and recent knowledge regarding the role of retinoid receptors in lung carcinogenesis. Sensitive and appropriate biological tools are necessary for screening the risk population and monitoring the efficacy of chemoprevention. Investigation of retinoid receptors is important and may contribute to the establishment of new strategies in chemoprevention for high-risk patients and in the treatment of lung cancer.

引用

页数：7

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