Protective effect of Alpinetin on rats with chronic obstructive pulmonary disease

被引：18
作者：
Su, Yu [1 ]
Tao, Xianqi [1 ]
Xu, Jianghui [1 ]
机构：
[1] Anqing Municipal Hosp, Pharmaceut Adm Sect, Anqing, Peoples R China
来源：
FOOD SCIENCE & NUTRITION | 2020年 / 8卷 / 12期
关键词：
Alpinetin; apoptosis; COPD; inflammatory factor; pulmonary fibrosis; ACTIVATION; ALPHA; CHINA;
D O I：
10.1002/fsn3.1952
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
To investigate the function and mechanism of Alpinetin on chronic obstructive pulmonary disease (COPD) in rat model. The markers of lung injury (body weight/pulmonary function) were measured, and the protein levels of inflammatory-, apoptosis-, and fibrotic-related were determined by Western blot. HE/TUNEL/Masson staining was performed to investigate the mechanisms involved. The levels of inflammatory factors lung injury were detected by ELISA. The in vivo activities of all molecules were determined using a rat model. Alpinetin suppressed the injury of alveolus pulmonis cells occurred in vivo due to the decrease in inflammatory factors and biochemical markers by reduced the expression of TGF-beta 1, alpha-SMA, and TNF-alpha (p < .05), associated with the declined of Caspase-3 and Caspase-9 (p < .01). Additionally, protective affection of Alpinetin downregulated the IL-6 and upregulated the IL-10 (p < .01). Protective affection of Alpinetin inhibits the apoptosis, inflammation, and fibrosis of alveolus pulmonis cells in rat models.
引用
收藏
页码：6603 / 6611
页数：9
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