Effect of vitamin D3 on thyroid function and de-iodinase 2 expression in diabetic rats

被引：20

作者：

Alrefaie, Zienab ^{[1
,2
]}

Awad, Hossam ^{[1
,3
]}

机构：

[1] King Abdulaziz Univ, Fac Med, Dept Physiol, Jeddah 21413, Saudi Arabia

[2] Cairo Univ, Fac Med, Dept Physiol, Giza, Egypt

[3] Ain Shams Univ, Dept Physiol, Fac Med, Cairo, Egypt

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2015年 / 121卷 / 05期

关键词：

Deiodinase; 2; diabetes mellitus; thyroid hormones; vitamin D-3; IODOTHYRONINE DEIODINASE; MELLITUS; ASSOCIATION; HORMONE;

D O I：

10.3109/13813455.2015.1107101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Objective: This study aimed to assess the effect of vitamin D-3 administration to diabetic rats on thyroid profile and deiodinase 2 (D2). Methods: Thirty male Wistar rats were included into three groups; control, streptozotocin-induced diabetic and diabetic supplemented with vitamin D-3 groups. Ten weeks later, serum levels of free T-4, free T-3 and TSH were measured. Tissue homogenates from liver, kidney, muscle, femur bone, heart and brain were obtained and assessed for D2 mRNA. Results: Diabetic rats demonstrated significant increase in free T-4 and significant decrease in free T-3. These changes were ameliorated by vitamin D-3 administration. D2 mRNA was significantly reduced in all tissue homogenates obtained from diabetic rats, while vitamin D-3 treatment significantly enhanced D2 in liver and brain homogenates. Conclusion: Diabetes mellitus inhibited peripheral conversion of T-4 into T-3 secondary to reduction in D2 expression. Vitamin D-3 greatly corrected the alterations in thyroid profile and D2 expression.

引用

页码：206 / 209

页数：4

共 24 条

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