Non-canonical WNT signalling in the lung

被引：35

作者：

Li, Changgong ^{[1
,2
]}

Bellusci, Saverio ^{[3
,4
,5
]}

Borok, Zea ^{[6
]}

Minoo, Parviz ^{[1
,2
]}

机构：

[1] Univ So Calif, Keck Sch Med, Los Angeles Cty Univ Soouthern Calif Med Ctr, Dept Pediat,Div Newborn Med, Los Angeles, CA 90033 USA

[2] Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Los Angeles, CA 90033 USA

[3] Excellence Cluster Cardiopulm Syst ECCPS, D-35392 Giessen, Hessen, Germany

[4] Childrens Hosp Los Angeles, Saban Res Inst, Dev Biol & Regenerat Med Program, Los Angeles, CA 90027 USA

[5] Univ So Calif, Los Angeles, CA 90027 USA

[6] Univ So Calif, Keck Sch Med, Will Rogers Inst, Pulm Res Ctr,Dept Med,Div Pulm Crit Care & Sleep, Los Angeles, CA 90033 USA

来源：

JOURNAL OF BIOCHEMISTRY | 2015年 / 158卷 / 05期

关键词：

development; lung; non-canonical; WNT; RECEPTOR TYROSINE KINASE; OBSTRUCTIVE PULMONARY-DISEASE; AIRWAY SMOOTH-MUSCLE; BETA-CATENIN; STEM-CELLS; MESENCHYMAL TRANSITION; ENDOTHELIAL-CELLS; XENOPUS EMBRYOS; PATHWAY; REGENERATION;

D O I：

10.1093/jb/mvv081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of WNT signalling in metazoan organogenesis has been a topic of widespread interest. In the lung, while the role of canonical WNT signalling has been examined in some detail by multiple studies, the non-canonical WNT signalling has received limited attention. Reliable evidence shows that this important signalling mechanism constitutes a major regulatory pathway in lung development. In addition, accumulating evidence has also shown that the non-canonical WNT pathway is critical for maintaining lung homeostasis and that aberrant activation of this pathway may underlie several debilitating lung diseases. Functional analyses have further revealed that the non-canonical WNT pathway regulates multiple cellular activities in the lung that are dependent on the specific cellular context. In most cell types, non-canonical WNT signalling regulates canonical WNT activity, which is also critical for many aspects of lung biology. This review will summarize what is currently known about the role of non-canonical WNT signalling in lung development, homeostasis and pathogenesis of disease.

引用

页码：355 / 365

页数：11

共 94 条

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