Novel taxanes from the needles of Taxus canadensis

被引：24
作者：
Zamir, LO
Zhang, JZ
Wu, JH
Sauriol, F
Mamer, O
机构：
[1] Univ Quebec, Inst Armand Frappier, INRS, Human Hlth Res Ctr, Laval, PQ H7V 1B7, Canada
[2] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
[3] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada
[4] McGill Univ, Biomed Mass Spectrometry Unit, Montreal, PQ H3A 1A3, Canada
来源：
TETRAHEDRON | 1999年 / 55卷 / 50期
基金：
加拿大自然科学与工程研究理事会;
关键词：
natural product; antitumour compounds; taxoids; epoxides;
D O I：
10.1016/S0040-4020(99)00930-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nineteen taxanes were characterized for the first time in the needles of the Canadian yew. Four of these metabolites are novel: taxinine-11, 12-oxide (1), 7-acetoxytaxuspine C (2), 5-cinnamoyltaxin B (3), and 7, 9-deacetyltaxinine B (4). Compound 1 is the second 11,12-epoxy-taxane known and 7-oxygenated-3, 11-cyclotaxane structures are unique to Taxus canadensis. In addition, taxinine and taxinine E were found to be major taxanes in the Canadian yew. The structures of all the taxanes were rigorously established by spectroscopic methods. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：14323 / 14340
页数：18
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