Systems Biology of Monovalent Cation Homeostasis in Yeast: The Translucent Contribution

被引：19

作者：

Arino, Joaquin ^{[1
,2
]}

Aydar, Ebru ^{[3
]}

Drulhe, Samuel ^{[4
]}

Ganser, Daniel ^{[5
]}

Jorrin, Jesus ^{[6
]}

Kahm, Matthias ^{[7
]}

Krause, Falko ^{[4
]}

Petrezselyova, Silvia ^{[1
,2
]}

Yenush, Lynne ^{[8
]}

Zimmermannova, Olga ^{[9
]}

van Heusden, G. Paul H. ^{[10
]}

Kschischo, Maik ^{[7
]}

Ludwig, Jost ^{[5
]}

Palmer, Chris ^{[3
]}

Ramos, Jose ^{[11
]}

Sychrova, Hana ^{[9
]}

机构：

[1] Univ Autonoma Barcelona, Inst Biotecnol Biomed, E-08193 Barcelona, Spain

[2] Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, E-08193 Barcelona, Spain

[3] London Metropolitan Univ, Fac Life Sci & Comp, London, England

[4] Humboldt Univ, D-10099 Berlin, Germany

[5] Univ Bonn, Bonn, Germany

[6] Univ Cordoba, Dept Biochem & Mol Biol, Cordoba, Spain

[7] Univ Appl Sci Koblenz, Remagen, Germany

[8] Univ Politecn Valencia, Consejo Super Invest Cientif, Inst Biol Mol & Celular Plantas, E-46071 Valencia, Spain

[9] Acad Sci CR, Inst Physiol, Dept Membrane Transport, Prague, Czech Republic

[10] Leiden Univ, Inst Biol, Leiden, Netherlands

[11] Univ Cordoba, Dept Microbiol, Cordoba, Spain

来源：

ADVANCES IN MICROBIAL SYSTEMS BIOLOGY | 2014年 / 64卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

SACCHAROMYCES-CEREVISIAE WILD; TRK1 POTASSIUM TRANSPORTER; HAL5; PROTEIN-KINASES; PLASMA-MEMBRANE; TRANSCRIPTION FACTOR; NUCLEAR-LOCALIZATION; QUANTITATIVE MODEL; POSITIVE REGULATOR; MOLECULAR ANALYSIS; SIGNALING PATHWAY;

D O I：

10.1016/B978-0-12-800143-1.00001-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maintenance of monovalent cation homeostasis (mainly K+ and Na+) is vital for cell survival, and cation toxicity is at the basis of a myriad of relevant phenomena, such as salt stress in crops and diverse human diseases. Full understanding of the importance of monovalent cations in the biology of the cell can only be achieved from a systemic perspective. Translucent is a multinational project developed within the context of the SysMO (System Biology of Microorganisms) initiative and focussed in the study of cation homeostasis using the well-known yeast Saccharomyces cerevisiae as a model. The present review summarize how the combination of biochemical, genetic, genomic and computational approaches has boosted our knowledge in this field, providing the basis for a more comprehensive and coherent vision of the role of monovalent cations in the biology of the cell.

引用

页码：1 / 63

页数：63

共 142 条

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