Puerarin inhibits EMT induced by oxaliplatin via targeting carbonic anhydrase XII

被引：11

作者：

Chen, Xindong ^{[1
]}

Zhou, Zhiruo ^{[2
,3
]}

Zhang, Zhi ^{[1
]}

Zhao, Chenhao ^{[1
]}

Li, Jiayu ^{[1
]}

Jiang, Jingwen ^{[1
]}

Huang, Biao ^{[1
]}

Qin, Yuan ^{[1
]}

机构：

[1] Zhejiang Sci Tech Univ, Coll Life Sci & Med, Hangzhou, Peoples R China

[2] Zhejiang Gongshang Univ, Sch Environm Sci & Engn, Hangzhou, Peoples R China

[3] Zhejiang Prov Key Lab Solid Waste Treatment & Rec, Hangzhou, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

关键词：

puerarin; oxaliplatin; breast cancer; epithelial-mesenchymal transition; carbonic anhydrase XII; BREAST-CANCER; IN-VITRO; EXPRESSION; CARCINOMA; CHEMOTHERAPY; INDUCTION; MIGRATION; INVASION; IX;

D O I：

10.3389/fphar.2022.969422

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Puerarin is a flavonoid molecule that widely exists in various plants. Puerarin has been reported to exhibit anti-tumor effects in various cancers. However, its exact underlying pharmacological mechanism is unclear. This study evaluated the anticancer effect of puerarin combined with oxaliplatin (OXA) in vitro and in vivo. Our results indicated that puerarin can reverse platinum-based anti-cancer drug resistance, and enhance the OXA's anticancer effects on breast cancer. Furthermore, puerarin can inhibit migration and reverse the epithelial-mesenchymal transition (EMT) induced by low-dose OXA. Further studies showed that the carbonic anhydrase (CA) XII is a potential target of puerarin. In conclusion, puerarin is expected to become an adjuvant chemotherapy drug and potentially become one of the medicated foods for breast cancer patients.

引用

页数：10

共 40 条

[1] Isoflavones derived from plant raw materials: bioavailability, anti-cancer, anti-aging potentials, and microbiome modulation [J].

Aboushanab, Saied A. ;

Khedr, Shaimaa M. ;

Gette, Irina F. ;

Danilova, Irina G. ;

Kolberg, Natalia A. ;

Ravishankar, Gokare A. ;

Ambati, Ranga Rao ;

Kovaleva, Elena G. .

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2022, 63 (02) :261-287

[2] Molecular Mechanisms of Anticancer Activities of Puerarin [J].

Ahmad, Bashir ;

Khan, Suliman ;

Liu, Yang ;

Xue, Mengzhou ;

Nabi, Ghulam ;

Kumar, Sunjeet ;

Alshwmi, Mohammed ;

Qarluq, Abdul Wakeel .

CANCER MANAGEMENT AND RESEARCH, 2020, 12 :79-90

[3] Flavonoids as anticancer therapies: A systematic review of clinical trials [J].

Bisol, Angela ;

de Campos, Paloma Santos ;

Lamers, Marcelo Lazzaron .

PHYTOTHERAPY RESEARCH, 2020, 34 (03) :568-582

[4] Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells [J].

Chen, Huei-Mei ;

Wu, Yang-Chang ;

Chia, Yi-Chen ;

Chang, Fang-Rong ;

Hsu, Hseng-Kuang ;

Hsieh, Ya-Ching ;

Chen, Chih-Chen ;

Yuan, Shyng-Shiou .

CANCER LETTERS, 2009, 286 (02) :161-171

[5] In vitro and in vivo antitumour activities of puerarin 6-O-xyloside on human lung carcinoma A549 cell line via the induction of the mitochondria-mediated apoptosis pathway [J].

Chen, Ti ;

Chen, Hui ;

Wang, Ying ;

Zhang, Jian .

PHARMACEUTICAL BIOLOGY, 2016, 54 (09) :1793-1799

[6] Establishment and clinical application of time-resolved immunofluorescence assay of lipoprotein-associated phospholipase A2 [J].

Chen, Xindong ;

Zhou, Kewen ;

Xiang, Zhongyi ;

Zhou, Xiumei ;

Wang, Yigang ;

Hong, Jianfeng ;

Huang, Biao ;

Qin, Yuan ;

Fang, Hongming .

ANALYTICAL BIOCHEMISTRY, 2022, 648

[7] Multiple roles of mothers against decapentaplegic homolog 4 in tumorigenesis, stem cells, drug resistance, and cancer therapy [J].

Dai, Chuan-Jing ;

Cao, Yu-Ting ;

Huang, Fang ;

Wang, Yi-Gang .

WORLD JOURNAL OF STEM CELLS, 2022, 14 (01) :41-53

[8] Carbonic anhydrase XII promotes invasion and migration ability of MDA-MB-231 breast cancer cells through the p38 MAPK signaling pathway [J].

Hsieh, Ming-Ju ;

Chen, Kuo-Shuen ;

Chiou, Hui-Ling ;

Hsieh, Yih-Shou .

EUROPEAN JOURNAL OF CELL BIOLOGY, 2010, 89 (08) :598-606

[9] Puerarin inhibits non-small cell lung cancer cell growth via the induction of apoptosis [J].

Hu, Yefang ;

Li, Xi ;

Lin, Ling ;

Liang, Siting ;

Yan, Jian .

ONCOLOGY REPORTS, 2018, 39 (04) :1731-1738

[10] Overexpression of carbonic anhydrase XII in tissues from resectable non-small cell lung cancers is a biomarker of good prognosis [J].

Ilie, Marius I. ;

Hofman, Veronique ;

Ortholan, Cecile ;

El Ammadi, Reda ;

Bonnetaud, Christelle ;

Havet, Katia ;

Venissac, Nicolas ;

Mouroux, Jerome ;

Mazure, Nathalie M. ;

Pouyssegur, Jacques ;

Hofman, Paul .

INTERNATIONAL JOURNAL OF CANCER, 2011, 128 (07) :1614-1623

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