Is the LDL receptor involved in cortical amyloid protein clearance?

被引：17

作者：

Abdulkarim, Yasir ^{[1
]}

Hameed, Zeyad

机构：

[1] St Johns Hosp, Livingston EH54 6PS, Scotland

[2] St Marys Hosp, Dublin, Ireland

来源：

NEUROCHEMICAL RESEARCH | 2006年 / 31卷 / 06期

关键词：

LDL receptor; statins; amyloid protein;

D O I：

10.1007/s11064-006-9084-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article puts forward the hypothesis that the Low Density Lipid Receptor (LDLR) is one of the molecules that is involved in the clearance of amyloid proteins in the brain and that it may play a role in Alzheimer's Disease (AD) via its up-regulation by statins. The hypothesis is built on the following observations: a-statins (which have been shown to increase LDLR in astrocytes, see below) have a beneficial role in AD, b-defects in the LDL receptor gene are found in AD, c-molecules with similar structure to the LDLR have been shown to clear amyloid protein from the brain.

引用

收藏

页码：839 / 847

页数：9

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