Synthesis of 1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde

被引：0
|
作者：
Wang, Caolin [1 ]
Tu, Yuanbiao [1 ]
Han, Jiaqian [1 ]
Guo, Yuping [1 ]
机构：
[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China
来源：
PROCEEDINGS OF THE 2016 7TH INTERNATIONAL CONFERENCE ON EDUCATION, MANAGEMENT, COMPUTER AND MEDICINE (EMCM 2016) | 2017年 / 59卷
关键词：
1H-pyrrole-2-carbaldehyde; Synthesis; TYROSINASE INHIBITORS; ACID;
D O I：
暂无
中图分类号：
F [经济];
学科分类号：
02 ;
摘要：
1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carb aldehyde 4a-b is a new aqueous solubility aldehyde as an important intermediates of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds 4a-b was established. The compound 4a-b was synthesized from the commercially available pyrrole through three steps including acylation and two steps nucleophilic substitution. The structure was confirmed by MS and 'HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65%.
引用
收藏
页码：603 / 605
页数：3
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