Microparticulated systems based on chitosan and poly(vinyl alcohol) with potential ophthalmic applications

被引：13

作者：

Cadinoiu, Anca Niculina ^{[1
,2
]}

Peptu, Catalina Anisoara ^{[2
]}

Fache, Bernard ^{[3
]}

Chailan, Jean-Francois ^{[3
]}

Popa, Marcel ^{[2
]}

机构：

[1] Apollonia Univ Iasi, Acad Ioan Haulica Res Inst, Fac Med Dent, Iasi, Romania

[2] Gheorghe Asachi Tech Univ Iasi, Fac Chem Engn & Environm Protect, Dept Nat & Synthet Polymers, Iasi 700050, Romania

[3] Univ Sud Toulon Var, Mat Polymeres Interfaces Environm Marin MAPIEM La, La Garde, France

来源：

JOURNAL OF MICROENCAPSULATION | 2015年 / 32卷 / 04期

关键词：

Chitosan; double crosslinking; microparticles; poly(vinyl alcohol); pilocarpine; DRUG-DELIVERY-SYSTEM; POLYVINYL-ALCOHOL; NANOPARTICLES; POLYMERS; HYDROGELS; GELATIN; RELEASE; FILMS;

D O I：

10.3109/02652048.2015.1035682

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Spherical microparticles for encapsulation of drugs for the treatment of diseases, with a diameter ranging between 2 and 4 mu m, were obtained by double crosslinking (ionic and covalent) of chitosan and poly(vinyl alcohol) blend in a water-in-oil emulsion. Microparticles characterisation was carried out in terms of structural, morphological and swelling properties in aqueous media. The presence of chitosan in particles composition confers them a pH-sensitive character. Toxicity and hemocompatibility tests prove the biocompatible character of microparticles. The pilocarpine loading capacity is high as well as the release efficiency which increases up to 72 and 82% after 6 h. The obtained results recommend the microparticles as sustained release drug carriers for the treatment of eye diseases.

引用

页码：381 / 389

页数：9

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