Synthesis and Biological Evaluation of N-Phenyl-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines

被引：2

作者：

Zhang, Mu ^{[1
]}

Luo, Xiai ^{[1
]}

Zhu, Daizheng ^{[1
]}

Zhang, Xuepeng ^{[1
]}

Liu, Feng ^{[1
]}

Fang ^{[2
]}

Liu, Jianbing ^{[1
]}

机构：

[1] Hunan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Hunan, Peoples R China

[2] Nankai Univ, Res Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 33卷 / 09期

关键词：

2-aminothiazole; 1H-1,2,4-triazole; synthesis; biological activities; DERIVATIVES; THIAZOLE;

D O I：

10.6023/cjoc201304010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thirteen new N-phenyl-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines were synthesized using Hantzsch reaction. Their structures of all these new compounds have been confirmed by H-1 NMR, MS and elemental analysis. It is found that the solvent used in the reaction has important influence on the synthesis of the title compounds containing different substituent. Their results of bioassay showed that all title compounds exhibited some degree of antifungal activities. Compound 6c against A. solani and P. piricola, compound 6g against A. solani, compound 6h against C. cucumerinum and compound 6i against P. piricola displayed above 80% inhibition, respectively.

引用

页码：1955 / 1959

页数：5

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