Neoadjuvant treatment strategies for intrahepatic cholangiocarcinoma

被引：56

作者：

Akateh, Clifford ^{[1
]}

Ejaz, Aslam M. ^{[2
]}

Pawlik, Timothy Michael ^{[1
]}

Cloyd, Jordan M. ^{[2
]}

机构：

[1] Ohio State Univ, Wexner Med Ctr, Dept Surg, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Surg, 410 W 10th Ave,N-907, Columbus, OH 43210 USA

来源：

WORLD JOURNAL OF HEPATOLOGY | 2020年 / 12卷 / 10期

关键词：

Biliary tract cancer; Preoperative therapy; Conversion therapy; Down-staging; Hepatectomy; Liver resection; TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; BILIARY-TRACT CANCER; PRIMARY LIVER-CANCER; PORTAL-VEIN EMBOLIZATION; SURGICAL MARGIN STATUS; UNRESECTABLE CHOLANGIOCARCINOMA; Y-90; RADIOEMBOLIZATION; TRANSARTERIAL CHEMOEMBOLIZATION; HEPATIC RESECTION; PROGNOSTIC-FACTOR;

D O I：

10.4254/wjh.v12.i10.693

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy and is increasing in incidence. Long-term outcomes are optimized when patients undergo margin-negative resection followed by adjuvant chemotherapy. Unfortunately, a significant proportion of patients present with locally advanced, unresectable disease. Furthermore, recurrence rates are high even among patients who undergo surgical resection. The delivery of systemic and/or liver-directed therapies prior to surgery may increase the proportion of patients who are eligible for surgery and reduce recurrence rates by prioritizing early systemic therapy for this aggressive cancer. Nevertheless, the available evidence for neoadjuvant therapy in ICC is currently limited yet recent advances in liver directed therapies, chemotherapy regimens, and targeted therapies have generated increasing interest its role. In this article, we review the rationale for, current evidence for, and ongoing research efforts in the use of neoadjuvant therapy for ICC.

引用

页码：693 / 708

页数：16

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