Porcine epidemic diarrhea virus: Molecular mechanisms of attenuation and vaccines

被引：90

作者：

Li, Zhiwei ^{[1
]}

Ma, Zhiqian ^{[1
]}

Li, Yang ^{[1
]}

Gao, Sheng ^{[1
]}

Xiao, Shuqi ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Vet Med, 22 Xining Rd, Yangling 712100, Shaanxi, Peoples R China

来源：

MICROBIAL PATHOGENESIS | 2020年 / 149卷

关键词：

Porcine epidemic diarrhea virus; Vaccine; Virulence; Genetics; RESPIRATORY SYNDROME-CORONAVIRUS; PAPAIN-LIKE PROTEASE; NF-KAPPA-B; TRANSMISSIBLE GASTROENTERITIS VIRUS; ENDOPLASMIC-RETICULUM STRESS; INFECTIOUS-BRONCHITIS VIRUS; MESSENGER-RNA VACCINES; MURINE HEPATITIS-VIRUS; PROLONGS S-PHASE; SARS-CORONAVIRUS;

D O I：

10.1016/j.micpath.2020.104553

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Porcine epidemic diarrhea virus (PEDV) causes an emerging and re-emerging coronavirus disease characterized by vomiting, acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets, leading to huge economic losses in the global swine industry. Vaccination remains the most promising and effective way to prevent and control PEDV. However, effective vaccines for PEDV are still under development. Understanding the genomic structure and function of PEDV and the influence of the viral components on innate immunity is essential for developing effective vaccines. In the current review, we systematically describe the recent developments in vaccine against PEDV and the roles of structural proteins, non-structural proteins and accessory proteins of PEDV in affecting viral virulence and regulating innate immunity, which will provide insight into the rational design of effective and safe vaccines for PEDV or other coronaviruses.

引用

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