Phosphorylation regulates Id3 function in vascular smooth muscle cells

被引：26

作者：

Forrest, ST

Taylor, AM

Sarembock, IJ

Perlegas, D

McNamara, CA ^{[1
]}

机构：

[1] Univ Virginia, Hlth Sci Ctr, Dept Internal Med, Div Cardiovasc, Charlottesville, VA 22908 USA

[2] Univ Virginia, Hlth Sci Ctr, Cardiovasc Res Ctr, Charlottesville, VA 22908 USA

来源：

CIRCULATION RESEARCH | 2004年 / 95卷 / 06期

关键词：

muscle; vascular; smooth; cell cycle; helix-loop-helix motifs; phosphorylation;

D O I：

10.1161/01.RES.0000142735.67542.5a

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Understanding the mechanisms that regulate cell cycle progression in vascular smooth muscle cells (VSMCs) is key to understanding and modulating vascular lesion formation. Results of the present study provide the first evidence that phosphorylation of the helix-loop-helix factor Id3 in VSMCs occurs in vitro and in vivo and provides a regulatory switch controlling Id3-induced regulation of p21Cip1 and VSMC growth.

引用

收藏

页码：557 / 559

页数：3

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