Structural and functional analogue of the active site of polysulfide reductase from Wolinella succinogenes

被引：26

作者：

Nagarajan, K

Joshi, HK

Chaudhury, PK

Pal, K

Cooney, JJA

Enemark, JH ^{[1
]}

Sarkar, S

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

INORGANIC CHEMISTRY | 2004年 / 43卷 / 15期

关键词：

D O I：

10.1021/ic049665i

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Synthesis of [PPh4](2)[Mo(SPh)(2)(S2C2(CN)(2))(2)] (2) from [PPh4](2)[MoO(S2C2(CN)(2))(2)] (1) has been achieved to mimic the postulated {Mo(S)(6)} core of polysulfide reductase with two thiolates and two bis(ene-dithiolate) ligands. Compound 2 reacts with polysulfide to yield H2S, modeling the function of polysulfide reductase. The facile conversion of 2 back to 1 in moist solvent suggests that the interconversion of the {Mo-IV=O} and {Mo-IV-X} (X = O-Ser, S-Cys, Se-Cys) moieties might occur in the DMSO reductase class of enzymes under appropriate hydrophobic/hydrophilic conditions.

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页码：4532 / 4533

页数：2

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