At the end of the 1960s, western countries have put forward to the "human-oriented" design thinking. This is a significant leap in thinking in the history of the design. However, complexity and uncertainty of the "human" factor of the "human-oriented" design thinking determine the relativity and limitation of its ideological foundation for the design. Meanwhile the "human-oriented" design thinking exist relative limitations. A "human, machine and environment" comprehensive systematic design should be established for product design. This is also the social responsibility and historical mission of designers.