Surface Functionalization of Chemically Reduced Graphene Oxide for Targeted Photodynamic Therapy

被引：67

作者：

Huang, Peng ^{[1
,2
]}

Wang, Shouju ^{[2
]}

Wang, Xiansong ^{[3
]}

Shen, Guangxia ^{[3
]}

Lin, Jing ^{[2
]}

Wang, Zhe ^{[2
,4
]}

Guo, Shouwu ^{[3
]}

Cui, Daxiang ^{[3
]}

Yang, Min ^{[1
]}

Chen, Xiaoyuan ^{[2
]}

机构：

[1] Jiangsu Inst Nucl Med, Key Lab Nucl Med, Jiangsu Key Lab Mol Nucl Med, Minist Hlth, Wuxi 214063, Jiangsu, Peoples R China

[2] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA

[3] Shanghai Jiao Tong Univ, Res Inst Micro Nano Sci & Technol, Shanghai 200240, Peoples R China

[4] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361005, Peoples R China

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2015年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Graphene Oxide; Polyvinylpyrrolidone; Chlorin e6; RGD; Photodynamic Therapy; GOLD NANOPARTICLES; CELLULAR UPTAKE; POLYVINYLPYRROLIDONE; THERANOSTICS; DELIVERY; PEPTIDE; DOTS; SIZE;

D O I：

10.1166/jbn.2015.2055

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this study, using chemically reduced graphene oxide (GO) as a model nanocarbon, we successfully developed a facile surface-functionalization strategy of nanocarbons to allow both biocompatibility and receptor targeted drug delivery. Polyvinylpyrrolidone (PVP) coating improves aqueous dispersibility and biocompatibility of GO, and provides anchoring sites for ACDCRGDCFCG peptide (RGD4C). Aromatic photosensitizer chlorin e6 (Ce6) can be effectively loaded into the rGO-PVP-RGD system via hydrophobic interactions and pi-pi stacking. The nanodelivery system can significantly increase the accumulation of Ce6 in tumor cells and lead to an improved photodynamic therapy (PDT) efficacy as compared to Ce6 alone. The facile surface functionalization strategy can be applied to other nanomaterials such as carbon nanotubes, and inorganic nanomaterials.

引用

页码：117 / 125

页数：9

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