Long-term improvement of lung clearance index in patients with mild cystic fibrosis lung disease: Does hypertonic saline play a role?

被引：12
作者：
Ellemunter, Helmut [1 ]
Eder, Johannes [1 ]
Fuchs, Susanne [2 ]
Gappa, Monika [3 ]
Steinkamp, Gratiana [4 ]
机构：
[1] Med Univ Innsbruck, Dept Child & Adolescent Hlth, Div Cardiol Pulmonol Allergol & Cyst Fibrosis, Cyst Fibrosis Ctr, Anichstr 35, A-6020 Innsbruck, Austria
[2] Marien Hosp Wesel, Childrens Hosp & Res Inst, Pastor Janssen Str 8-38, D-46483 Wesel, Germany
[3] Marien Hosp Wesel gGmbH, Marien Hosp Wesel, Childrens Hosp & Res Inst, Pastor Janssen Str 8-38, D-46483 Wesel, Germany
[4] Clin Res, Reutzstr 1, D-19055 Schwerin, Germany
来源：
JOURNAL OF CYSTIC FIBROSIS | 2016年 / 15卷 / 01期
关键词：
CHEST COMPUTED-TOMOGRAPHY; CLINICAL-TRIALS; YOUNG-CHILDREN; CF;
D O I：
10.1016/j.jcf.2015.06.009
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
To assess whether long-term inhalation with hypertonic saline is able to halt the progression of mild CF lung disease, we analysed longitudinal data of lung clearance index (LCI) and spirometry. A total of 34 patients with mild lung disease (FEV1 >= 70% of predicted) had at least one LCI result before and >= 2 LCI measurements after start of hypertonic saline (HS) therapy. After a mean follow-up of 39.7 (SD 7.4) months after starting HS, LCI improved significantly from 7.89 (SD 1.35) at baseline to 6.96 (SD 1.03), and 19/34 patients had a normal LCI value at the last measurement. No decrease in mean FEV1 was observed. Thus, ventilation inhomogeneity can improve in patients with mild lung disease. (C) 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：123 / 126
页数：4
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