Hepatic Angiosarcoma with Dyskeratosis Congenita

被引：6

作者：

Horiguchi, Norio ^{[1
]}

Kakizaki, Satoru ^{[1
]}

Iizuka, Keisuke ^{[1
]}

Hagiwara, Satoshi ^{[1
]}

Ohyama, Tatsuya ^{[1
]}

Yamazaki, Yuichi ^{[1
]}

Shibusawa, Nobuyuki ^{[1
]}

Sato, Ken ^{[1
]}

Kusano, Motoyasu ^{[1
]}

Nakazato, Yoichi ^{[2
]}

Yamada, Masanobu ^{[1
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma, Japan

[2] Gunma Univ, Grad Sch Med, Dept Human Pathol, Maebashi, Gunma, Japan

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 22期

关键词：

hepatic angiosarcoma; dyskeratosis congenita; PHASE-II;

D O I：

10.2169/internalmedicine.54.5206

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nail dystrophy, oral leukoplakia and abnormal skin pigmentation are the defining features of dyskeratosis congenita. Dyskeratosis congenita is a disorder of poor telomere maintenance and is known to increase the risk of developing multiple types of malignancy. However, there are few reports of liver tumors arising in dyskeratosis congenita patients. We herein report the second case of hepatic angiosarcoma arising from dyskeratosis congenita: a 23-year-old man was introduced to our hospital due to the detection of multiple tumors in the liver. A histological analysis showed angiosarcoma that stained positive for antibodies to both CD31 and blood coagulation factor VIII.

引用

页码：2867 / 2872

页数：6

共 16 条

[1] An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas†
Agulnik, M.
Yarber, J. L.
Okuno, S. H.
von Mehren, M.
Jovanovic, B. D.
Brockstein, B. E.
Evens, A. M.
Benjamin, R. S.
[J]. ANNALS OF ONCOLOGY, 2013, 24 (01) : 257 - 263
[2] Cancer in dyskeratosis congenita
Alter, Blanche P.
Giri, Neelam
Savage, Sharon A.
Rosenberg, Philip S.
[J]. BLOOD, 2009, 113 (26) : 6549 - 6557
[3] Ballew BJ, 2013, EXPERT REV HEMATOL, V6, P327, DOI [10.1586/ehm.13.23, 10.1586/EHM.13.23]
[4] Dyskeratosis congenita with pigmentation, dystrophia unguis and leukokeratosis oris
Cole, HN
Rauschkolb, JE
Toomey, J
[J]. ARCHIVES OF DERMATOLOGY AND SYPHILOLOGY, 1930, 21 (01): : 71 - 95
[5] Dyskeratosis Congenita
Dokal, Inderjeet
[J]. HEMATOLOGY-AMERICAN SOCIETY HEMATOLOGY EDUCATION PROGRAM, 2011, : 480 - 486
[6] Engman M F., 1926, Arch Belg Dermatol Syphiligr, V13, P685
[7] Comparison of doxorubicin and weekly paclitaxel efficacy in metastatic angiosarcomas
Italiano, Antoine
Cioffi, Angela
Penel, Nicolas
Levra, Matteo Giaj
Delcambre, Corinne
Kalbacher, Elsa
Chevreau, Christine
Bertucci, Francois
Isambert, Nicolas
Blay, Jean-Yves
Bui, Binh
Antonescu, Cristina
D'Adamo, David R.
Maki, Robert G.
Keohan, Mary Louise
[J]. CANCER, 2012, 118 (13) : 3330 - 3336
[8] Primary hepatic angiosarcoma on coregistered FDG PET and CT images
Maeda, Tetsuo
Tateishi, Ukihide
Hasegawa, Tadashi
Ojima, Hidenori
Arai, Yasuaki
Sugimura, Kazuro
[J]. AMERICAN JOURNAL OF ROENTGENOLOGY, 2007, 188 (06) : 1615 - 1617
[9] The genetics of dyskeratosis congenita
Mason, Philip J.
Bessler, Monica
[J]. CANCER GENETICS, 2011, 204 (12) : 635 - 645
[10] Liver Failure Due to Hepatic Angiosarcoma in an Adolescent With Dyskeratosis Congenita
Olson, Timothy S.
Chan, Elaine S.
Paessler, Michele E.
Sullivan, Kathleen E.
Frantz, Christopher N.
Russo, Piere
Bessler, Monica
[J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2014, 36 (04) : 312 - 315

← 1 2 →