Hepatic Angiosarcoma with Dyskeratosis Congenita

被引：5

作者：

Horiguchi, Norio ^{[1
]}

Kakizaki, Satoru ^{[1
]}

Iizuka, Keisuke ^{[1
]}

Hagiwara, Satoshi ^{[1
]}

Ohyama, Tatsuya ^{[1
]}

Yamazaki, Yuichi ^{[1
]}

Shibusawa, Nobuyuki ^{[1
]}

Sato, Ken ^{[1
]}

Kusano, Motoyasu ^{[1
]}

Nakazato, Yoichi ^{[2
]}

Yamada, Masanobu ^{[1
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma, Japan

[2] Gunma Univ, Grad Sch Med, Dept Human Pathol, Maebashi, Gunma, Japan

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 22期

关键词：

hepatic angiosarcoma; dyskeratosis congenita; PHASE-II;

D O I：

10.2169/internalmedicine.54.5206

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nail dystrophy, oral leukoplakia and abnormal skin pigmentation are the defining features of dyskeratosis congenita. Dyskeratosis congenita is a disorder of poor telomere maintenance and is known to increase the risk of developing multiple types of malignancy. However, there are few reports of liver tumors arising in dyskeratosis congenita patients. We herein report the second case of hepatic angiosarcoma arising from dyskeratosis congenita: a 23-year-old man was introduced to our hospital due to the detection of multiple tumors in the liver. A histological analysis showed angiosarcoma that stained positive for antibodies to both CD31 and blood coagulation factor VIII.

引用

页码：2867 / 2872

页数：6

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