Fungal polyketide engineering comes of age

被引:4
作者
Agarwal, Vinayak [1 ]
Moore, Bradley S. [1 ,2 ]
机构
[1] Univ Calif San Diego, Ctr Oceans & Human Hlth, Scripps Inst Oceanog, San Diego, CA 92037 USA
[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, San Diego, CA 92037 USA
关键词
COMBINATORIAL BIOSYNTHESIS; NATURAL-PRODUCTS; SYNTHASE GENES; INSIGHTS; RADICICOL;
D O I
10.1073/pnas.1412946111
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:12278 / 12279
页数:2
相关论文
共 21 条
[1]   The role of natural product chemistry in drug discovery [J].
Butler, MS .
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (12) :2141-2153
[2]   Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules [J].
Chooi, Yit-Heng ;
Tang, Yi .
JOURNAL OF ORGANIC CHEMISTRY, 2012, 77 (22) :9933-9953
[3]   Deconstruction of iterative multidomain polyketide synthase function [J].
Crawford, Jason M. ;
Thomas, Paul M. ;
Scheerer, Jonathan R. ;
Vagstad, Anna L. ;
Kelleher, Neil L. ;
Townsend, Craig A. .
SCIENCE, 2008, 320 (5873) :243-246
[4]   Structure of a modular polyketide synthase [J].
Dutta, Somnath ;
Whicher, Jonathan R. ;
Hansen, Douglas A. ;
Hale, Wendi A. ;
Chemler, Joseph A. ;
Congdon, Grady R. ;
Narayan, Alison R. H. ;
Hakansson, Kristina ;
Sherman, David H. ;
Smith, Janet L. ;
Skiniotis, Georgios .
NATURE, 2014, 510 (7506) :512-+
[5]   Investigation of Fungal Iterative Polyketide Synthase Functions Using Partially Assembled Intermediates [J].
Gao, Zhizeng ;
Wang, Jingjing ;
Norquay, Amy K. ;
Qiao, Kangjian ;
Tang, Yi ;
Vederas, John C. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (05) :1735-1738
[6]   Structure of fungal fatty acid synthase and implications for iterative substrate shuttling [J].
Jenni, Simon ;
Leibundgut, Marc ;
Boehringer, Daniel ;
Frick, Christian ;
Mikolasek, Bohdan ;
Ban, Nenad .
SCIENCE, 2007, 316 (5822) :254-261
[7]   Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems [J].
Khosla, Chaitan ;
Herschlag, Daniel ;
Cane, David E. ;
Walsh, Christopher T. .
BIOCHEMISTRY, 2014, 53 (18) :2875-2883
[8]   Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase [J].
Ma, Suzanne M. ;
Li, Jesse W. -H. ;
Choi, Jin W. ;
Zhou, Hui ;
Lee, K. K. Michael ;
Moorthie, Vijayalakshmi A. ;
Xie, Xinkai ;
Kealey, James T. ;
Da Silva, Nancy A. ;
Vederas, John C. ;
Tang, Yi .
SCIENCE, 2009, 326 (5952) :589-592
[9]   Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products [J].
McDaniel, R ;
Thamchaipenet, A ;
Gustafsson, C ;
Fu, H ;
Betlach, M ;
Betlach, M ;
Ashley, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :1846-1851
[10]   Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes [J].
Menzella, HG ;
Reid, R ;
Carney, JR ;
Chandran, SS ;
Reisinger, SJ ;
Patel, KG ;
Hopwood, DA ;
Santi, DV .
NATURE BIOTECHNOLOGY, 2005, 23 (09) :1171-1176