A metal-free visible light promoted three-component facile synthesis of 4-oxo-tetrahydroindoles in ethanol-water

被引：10

作者：

Ansari, Khursheed ^{[1
]}

Nazeef, Mohd ^{[1
]}

Ali, Shabir ^{[2
]}

Waseem, Malik A. ^{[3
]}

Shah, Wajaht A. ^{[3
]}

Ansari, Saif ^{[1
]}

Siddiqui, Ibadur R. ^{[1
]}

Singh, Jagdamba ^{[4
]}

机构：

[1] Univ Allahabad, Dept Chem, Lab Green Synth, Allahabad 211002, Uttar Pradesh, India

[2] Aligarh Muslim Univ, Dept Chem, Aligarh, Uttar Pradesh, India

[3] Univ Kashmir, Dept Chem, Hazaratbal, India

[4] Univ Allahabad, Dept Chem, Allahabad, Uttar Pradesh, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 58卷 / 02期

关键词：

NATURAL-PRODUCT SYNTHESIS; MULTICOMPONENT REACTION; PHOTOREDOX CATALYSIS; C-H; 4-OXO-4,5,6,7-TETRAHYDROINDOLES; EFFICIENT; INDOLES; PHOTOCHEMISTRY; PHOTOPHYSICS; HETEROCYCLES;

D O I：

10.1002/jhet.4202

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient visible light-mediated one-pot multicomponent tandem approach to construct 4-oxo-tetrahydroindoles in ethanol-water medium at room temperature has been described. The characteristics of reported methodology are the utilization of visible light, an ideal source of energy to generate C-C and C-N bonds from commercially available substrates namely dimedone, phenacyl bromides, and amines. The presented protocol is highly compatible for developing 4-oxo-tetrahydroindole derivatives with improved selectivity and high yields. Moreover, metal-free synthesis, environmental friendly solvent, easy workup process, high atom economy, cost-effectiveness, short reaction time, and broad substratescope are the major advantages of reported protocol.

引用

页码：622 / 629

页数：8

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