Role of transcription factor acetylation in the regulation of metabolic homeostasis

被引：49

作者：

Park, Joo-Man ^{[1
]}

Jo, Seong-Ho ^{[1
]}

Kim, Mi-Young ^{[1
]}

Kim, Tae-Hyun ^{[1
]}

Ahn, Yong-Ho ^{[1
,2
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Biochem & Mol Biol, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Brain Korea PLUS Project Med Sci 21, Seoul 120752, South Korea

来源：

PROTEIN & CELL | 2015年 / 6卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

metabolic homeostasis; transcription factor; post-translational modification; type 2 diabetes mellitus; HEPATIC INSULIN-RESISTANCE; INDUCED GENE-EXPRESSION; CREB-BINDING PROTEIN; FORKHEAD TRANSCRIPTION; FACTOR FOXO1; C/EBP-BETA; PREADIPOCYTE DIFFERENTIATION; ADIPOSE-TISSUE; SREBP FAMILY; P300;

D O I：

10.1007/s13238-015-0204-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Post-translational modifications (PTMs) of transcription factors play a crucial role in regulating metabolic homeostasis. These modifications include phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, and O-GlcNAcylation. Recent studies have shed light on the importance of lysine acetylation at nonhistone proteins including transcription factors. Acetylation of transcription factors affects subcellular distribution, DNA affinity, stability, transcriptional activity, and current investigations are aiming to further expand our understanding of the role of lysine acetylation of transcription factors. In this review, we summarize recent studies that provide new insights into the role of protein lysine-acetylation in the transcriptional regulation of metabolic homeostasis.

引用

页码：804 / 813

页数：10

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