Evaluation of Glabridin loaded nanostructure lipid carriers

被引：10

作者：

Zhang, Chen ^{[1
]}

Luo, Shaoqiang ^{[1
]}

Zhang, Zhiwei ^{[3
]}

Niu, Yulian ^{[3
]}

Zhang, Wanping ^{[2
]}

机构：

[1] Infinitus China Co Ltd, Jiangmen 528156, Guangdong, Peoples R China

[2] Shanghai Inst Technol, Sch Perfume & Aroma Technol, 100 Haiquan Rd, Shanghai 201418, Peoples R China

[3] Shanghai Jointvace Co Ltd, Shanghai 200062, Peoples R China

来源：

JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS | 2017年 / 71卷

关键词：

Glabridin; TEM; Nanostructure lipid carriers; Photostability; IN-VITRO; TYROSINASE INHIBITORS; NANOPARTICLES SLN; DELIVERY; NLC; DRUG; ENCAPSULATION; PENETRATION; FORMULATION; STABILITY;

D O I：

10.1016/j.jtice.2016.11.010

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Effective use of Glabridin (GL) is limited by poor solubility, poor stability and unsatisfactory skin penetration in cosmetic products. To reduce such limitations, GL was formulated into nanostructure lipid carriers (NLCs) as a controlled-released system. The preparation and performance in vitro were evaluated. The effects of surfactant ratio (F127/SG) on the size and zeta potential were studied. The desirable particle size and zeta potential were obtained on the basis of F127/SG (surfactant ratio) weight ratio of 1:2. Transmission electron microscopy (TEM) and Differential Scanning Calorimetry showed GL was loaded in solid lipid matrix. Compared to conventional emulsion, GL-NLCs achieved prolonged release and localized the drug significantly better in the skin. The solid lipid matrix of NLCs reduced transmission of UV-rays to GL and it also retained the photostability of GL. As such, these results suggest the potential of NLCs for Glabridin delivery in cosmetic application. (C) 2016 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

引用

页码：338 / 343

页数：6

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