Unloosing the Gordian knot of peroxisome formation

被引:13
作者
Costello, Joseph L. [1 ]
Schrader, Michael [1 ]
机构
[1] Univ Exeter, Coll Life & Environm Sci, Biosci, Exeter EX4 4QD, Devon, England
基金
英国生物技术与生命科学研究理事会;
关键词
MEMBRANE-PROTEINS; IMPORT RECEPTOR; ENDOPLASMIC-RETICULUM; ER; MITOCHONDRIAL; BIOGENESIS; PROLIFERATION; REVEALS; GROWTH; ACBD5;
D O I
10.1016/j.ceb.2018.02.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Peroxisome biogenesis is governed by molecular machineries, which are either unique to peroxisomes or are partially shared with mitochondria. As peroxisomes have important protective functions in the cell, modulation of their number is important for human health and disease. Significant progress has been made towards our understanding of the mechanisms of peroxisome formation, revealing a remarkable plasticity of the peroxisome biogenesis pathway. Here we discuss most recent findings with particular focus on peroxisome formation in mammalian cells.
引用
收藏
页码:50 / 56
页数:7
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