Hydrotrifluoromethylthiolation of α-diazo esters - synthesis of α-SCF3 substituted esters

被引：105

作者：

Lefebvre, Quentin ^{[1
]}

Fava, Eleonora ^{[1
]}

Nikolaienko, Pavlo ^{[1
]}

Rueping, Magnus ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 50期

关键词：

NUCLEOPHILIC TRIFLUOROMETHYLTHIOLATION; 3-COMPONENT REACTION; CATALYZED SYNTHESIS; NATURAL-PRODUCTS; DIAZOACETATES; INSERTION; FLUORINE; REACTIVITY; REAGENTS; ALCOHOLS;

D O I：

10.1039/c4cc02060j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical protocol for hydrotrifluoromethylthiolation of diazo compounds has been developed. A range of diazo compounds in combination with a nucleophilic SCF3 source provided access to valuable trifluoromethylthiolated compounds. Furthermore, a methodology for the first double trifluoromethylthiolation was developed.

引用

页码：6617 / 6619

页数：3

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