Modification of electrospun poly(L-lactic acid)/polyethylenimine nanofibrous scaffolds for biomedical application

被引：22

作者：

Delyanee, Mahsa ^{[1
]}

Solouk, Atefeh ^{[1
]}

Akbari, Somaye ^{[2
]}

Seyedjafari, Ehsan ^{[3
]}

机构：

[1] Amirkabir Univ Technol, Dept Biomed Engn, Tehran, Iran

[2] Amirkabir Univ Technol, Dept Text Engn, Tehran, Iran

[3] Univ Tehran, Dept Biotechnol, Tehran, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2018年 / 67卷 / 04期

关键词：

Adipose-derived mesenchymal stem cells; biodegradation; gelatin grafting; poly(L-lactic acid); polyethylenimine hyperbranched; TISSUE ENGINEERING APPLICATIONS; ENDOTHELIAL-CELL ADHESION; SURFACE MODIFICATION; MECHANICAL-PROPERTIES; COMPOSITE MEMBRANE; POLY(LACTIC ACID)S; PLLA SCAFFOLDS; GENE DELIVERY; POLYETHYLENIMINE; GELATIN;

D O I：

10.1080/00914037.2017.1320661

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In this study, modification of poly(L-lactic acid) (PLLA) electrospun nanofibrous scaffolds blending with polyethylenimine (PEI) in different blend ratios was performed. The sample with 85: 15 blend ratio revealed most promising results, and was selected for further modification with gelatin. It was found that the presence of PEI could enhanced porosity, mechanical properties, surface/bulk hydrophilicity and also gelatin grafting density about five times with positive effect on cell behavior. The results indicated that the limitations of PLLA electrospun nanofibers for potential application as a functional tissue engineering scaffold (i.e., poor cell adhesion and necrosis of host tissues as a result of providing acidic environment while degradation) could be overcome through blending with PEI and grafting with gelatin. [GRAPHICS] .

引用

页码：247 / 257

页数：11

共 70 条

[31] Effect of fiber diameter, pore size and seeding method on growth of human dermal fibroblasts in electrospun poly(ε-caprolactone) fibrous mats [J].