Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review

被引:49
作者
Dinh, H. Cao [1 ,2 ]
Beyer, I. [1 ,3 ]
Mets, T. [1 ,2 ,3 ]
Onyema, O. O. [1 ,2 ]
Njemini, R. [1 ,2 ]
Renmans, W. [4 ]
De Waele, M. [4 ]
Jochmans, K. [4 ]
Vander Meeren, S. [4 ]
Bautmans, I. [1 ,2 ,3 ]
机构
[1] Vrije Univ Brussel, Frailty Ageing Res Grp, Laarbeeklaan 103, B-1090 Brussels, Belgium
[2] Vrije Univ Brussel, Gerontol Dept, Laarbeeklaan 103, B-1090 Brussels, Belgium
[3] Univ Ziekenhuis Brussel, Dept Geriatr, Laarbeeklaan 101, B-1090 Brussels, Belgium
[4] Univ Ziekenhuis Brussel, Hematol Lab, Laarbeeklaan 101, B-1090 Brussels, Belgium
关键词
Exercise; Immunosenescence; Elderly; Surface marker; NATURAL-KILLER-CELLS; CD57(+) T-CELLS; PERIPHERAL-BLOOD; IMMUNE FUNCTION; MODERATE EXERCISE; RECEPTOR G1; NK CELLS; IMMUNOLOGICAL PARAMETERS; LYMPHOCYTE APOPTOSIS; ANTIBODY-RESPONSE;
D O I
10.1007/s00223-016-0212-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aging affects negatively the immune system, defined as immunosenescence, which increases the susceptibility of elderly persons to infection, autoimmune disease, and cancer. There are strong indications that physical exercise in elderly persons may prevent the age-related decline in immune response without significant side effects. Consequently, exercise is being considered as a safe mode of intervention to reduce immunosenescence. The aim of this review was to appraise the existing evidence regarding the impact of exercise on surface markers of cellular immunosenescence in either young and old humans or animals. PubMed and Web of Science were systematically screened, and 28 relevant articles in humans or animals were retrieved. Most of the intervention studies demonstrated that an acute bout of exercise induced increases in senescent, na < ve, memory CD4(+) and CD8(+) T-lymphocytes and significantly elevated apoptotic lymphocytes in peripheral blood. As regards long-term effects, exercise induced increased levels of T-lymphocytes expressing CD28(+) in both young and elderly subjects. Few studies found an increase in natural killer cell activity following a period of training. We can conclude that exercise has considerable effects on markers of cellular aspects of the immune system. However, very few studies have been conducted so far to investigate the effects of exercise on markers of cellular immunosenescence in elderly persons. Implications for immunosenescence need further investigation.
引用
收藏
页码:193 / 215
页数:23
相关论文
共 118 条
[41]   Treadmill exercise in mice increases intestinal lymphocyte loss via apoptosis [J].
Hoffman-Goetz, L ;
Quadrilatero, J .
ACTA PHYSIOLOGICA SCANDINAVICA, 2003, 179 (03) :289-297
[42]   Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57 [J].
Ibegbu, CC ;
Xu, YX ;
Harris, W ;
Maggio, D ;
Miller, JD ;
Kourtis, AP .
JOURNAL OF IMMUNOLOGY, 2005, 174 (10) :6088-6094
[43]   Prolonged activation of virus-specific CD8+ T cells after acute B19 infection [J].
Isa, A ;
Kasprowicz, V ;
Norbeck, O ;
Loughry, A ;
Jeffery, K ;
Broliden, K ;
Klenerman, P ;
Tolfvenstam, T ;
Bowness, P .
PLOS MEDICINE, 2005, 2 (12) :1280-1291
[44]  
JENKINS MK, 1991, J IMMUNOL, V147, P2461
[45]  
Kapasi ZF, 2003, J GERONTOL A-BIOL, V58, P636
[46]   CD57 in human natural killer cells and T-lymphocytes [J].
Kared, Hassen ;
Martelli, Serena ;
Ng, Tze Pin ;
Pender, Sylvia L. F. ;
Larbi, Anis .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2016, 65 (04) :441-452
[47]   Cytomegalovirus infection -: A driving force in human T cell immunosenescence [J].
Koch, Sven ;
Larbi, Anis ;
Oezcelik, Dennis ;
Solana, Rafael ;
Gouttenfangeas, Cecile ;
Attig, Sebastian ;
Wikby, Anders ;
Strindhall, Jan ;
Franceschi, Claudio ;
Pawelec, Graham .
HEALTHY AGING AND LONGEVITY, 2007, 1114 :23-35
[48]   Moderate exercise improves antibody response to influenza immunization in older adults [J].
Kohut, ML ;
Arntson, BA ;
Lee, WL ;
Rozeboom, K ;
Yoon, KJ ;
Cunnick, JE ;
McElhaney, J .
VACCINE, 2004, 22 (17-18) :2298-2306
[49]   Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals [J].
Kohut, ML ;
Cooper, MM ;
Nickolaus, MS ;
Russell, DR ;
Cunnick, JE .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2002, 57 (09) :M557-M562
[50]   Inflammatory mediators in the elderly [J].
Krabbe, KS ;
Pedersen, M ;
Bruunsgaard, H .
EXPERIMENTAL GERONTOLOGY, 2004, 39 (05) :687-699