Domino synthesis of functionalized 1,6-naphthyridines and their in vitro anti-inflammatory and anti-oxidant efficacies

被引：11

作者：

Lavanya, Mallu ^{[1
]}

Thirumalai, Dhakshanamurthy ^{[2
]}

Asharani, Indira Viswambaran ^{[1
]}

Aravindan, P. Gopal ^{[3
]}

机构：

[1] VIT Univ, Sch Adv Sci, Environm & Analyt Chem Div, Vellore 632014, Tamil Nadu, India

[2] Thiruvalluvar Univ, Dept Chem, Vellore 632115, Tamil Nadu, India

[3] VIT Univ, Crystal Growth & Crystallog Div, Vellore 632014, Tamil Nadu, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 105期

关键词：

ONE-POT SYNTHESIS; EFFICIENT METHOD; BIOLOGICAL EVALUATION; CRYSTAL-STRUCTURE; DERIVATIVES; PYRIDINES; DESIGN; 5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINES; NAPHTHYRIDINES; SERIES;

D O I：

10.1039/c5ra11447k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bioactive 1,6-naphthyridines were constructed through a one pot multicomponent method by reacting different ketones with malononitrile and pyrrolidine. In vitro anti-inflammatory and 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activities for all the synthesized 1,6-naphthyridines were further carried out. These results clearly show that compound 3e exhibited excellent anti-inflammatory activity with a percentage inhibition of 81.24 +/- 4.46 by membrane stabilization method and 77.85 +/- 0.46 by the albumin denaturation method at a concentration of 100 mu g ml(-1), which is comparable to the standard diclofenac. A noticeable DPPH scavenging activity of 82.08 +/- 1.81% was also observed for the synthesized compound 3e when compared with the standard, ascorbic acid.

引用

页码：86330 / 86336

页数：7

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