Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

被引：12
|
作者：
Tran Dinh Thang [1 ]
Kuo, Ping-Chung [2 ]
Hwang, Tsong-Long [3 ,4 ]
Yang, Mei-Lin [5 ]
Nguyen Thi Bich Ngoc [1 ]
Tran Thi Ngoc Han [1 ]
Lin, Chi-Wen [2 ]
Wu, Tian-Shung [5 ]
机构：
[1] Vinh Univ, Dept Chem, Vinh City 42000, Nghe An, Vietnam
[2] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan
[3] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan
[4] Chang Gung Univ, Hlth Aging Res Ctr, Chinese Herbal Med Res Team, Tao Yuan 333, Taiwan
[5] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan
来源：
MOLECULES | 2013年 / 18卷 / 11期
关键词：
Ganoderma; triterpenoid; steroid; superoxide anion generation; elastase release; LANOSTANOIDS; CONSTITUENTS; EXTRACTS; LUCIDUM; TSUGAE;
D O I：
10.3390/molecules181114285
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14), 22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 +/- 0.38 and 1.94 +/- 0.50 mu g/mL, respectively.
引用
收藏
页码：14285 / 14292
页数：8
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