RETRACTED: Mitochondrial tRNA Mutations Associated With Essential Hypertension: From Molecular Genetics to Function (Retracted article. See vol. 10, 2022)

被引：10
作者：
Liu, Yuqi [1 ,2 ,3 ,4 ,5 ]
Chen, Yundai [6 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, Cardiac Dept, Beijing, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China
[4] Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Chron Heart Failure Precis Med, Beijing, Peoples R China
[5] Chinese Peoples Liberat Army Gen Hosp, Natl Key Lab Kidney Dis, Beijing, Peoples R China
[6] Chinese Peoples Liberat Army Gen Hosp, Cardiac Dept, Beijing, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 8卷
关键词：
tRNA; mtDNA; hypertension; maternal; mutation; MATERNALLY INHERITED CARDIOMYOPATHY; BLOOD-PRESSURE; FAMILIAL AGGREGATION; DNA MUTATION; HYPERTROPHIC CARDIOMYOPATHY; CALCIUM UNIPORTER; MTDNA MUTATION; METABOLISM; RISK; POPULATION;
D O I：
10.3389/fcell.2020.634137
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Essential hypertension (EH) is one of the most common cardiovascular diseases worldwide, entailing a high level of morbidity. EH is a multifactorial disease influenced by both genetic and environmental factors, including mitochondrial DNA (mtDNA) genotype. Previous studies identified mtDNA mutations that are associated with maternally inherited hypertension, including tRNA(Ile) m.4263A>G, m.4291T>C, m.4295A>G, tRNA(Met) m.4435A>G, tRNA(Ala) m.5655A>G, and tRNA(Met)/tRNA(Gln) m.4401A>G, et al. These mtDNA mutations alter tRNA structure, thereby leading to metabolic disorders. Metabolic defects associated with mitochondrial tRNAs affect protein synthesis, cause oxidative phosphorylation defects, reduced ATP synthesis, and increase production of reactive oxygen species. In this review we discuss known mutations of tRNA genes encoded by mtDNA and the potential mechanisms by which these mutations may contribute to hypertension.
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页数：12
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