Utility of activated nitriles in the synthesis of isoquinoline derivatives

被引：14

作者：

Fadda, AA

Refat, HM

机构：

[1] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt

[2] Suez Canal Univ, Fac Educ Al Arish, Dept Chem, Ismalia, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 02期

关键词：

D O I：

10.1080/00397910008087327

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

gamma-Cyano-gamma-(4-pyridyl) pimelonitrile ( 2 ) has been prepared by cyanoethylation of 4-pyridyl-acetonitrile ( 1 ). Hydrolysis of ( 2 ) using dil. HCl afford gamma- amido-gamma-(4-pyridyl) pimelic acid ( 3 ) which cyclized to the corresponding 3-(4-pyridyl)-2,6-piperidindione-3-propionic acid ( 4 ) by continuos heating in hydrochloric acid solution. Ring closure of ( 4 ) takes place in the presence of cone. sulphuric acid to give spiroisoquinoline derivative ( 5 ). Spiroisoquinoline derivatives ( 8 ) - ( 11 ) have been also prepared. Structure of all the products have been established by elemental and spectral analyses.

引用

页码：341 / 350

页数：10