The Stationary-Phase Sigma Factor σS Is Responsible for the Resistance of Escherichia coli Stationary-Phase Cells to mazEF-Mediated Cell Death

被引：11

作者：

Kolodkin-Gal, Ilana ^{[1
]}

Engelberg-Kulka, Hanna ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Mol Biol, IL-91120 Jerusalem, Israel

来源：

JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 09期

基金：

以色列科学基金会; 美国国家卫生研究院;

关键词：

TOXIN-ANTITOXIN LOCI; NUCLEOTIDE-SEQUENCE; MODULE; GENE; KATF; MITOCHONDRIA; MECHANISM; APOPTOSIS; PROTEINS; SYSTEM;

D O I：

10.1128/JB.00011-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Escherichia coli mazEF is a toxin-antitoxin gene module that mediates cell death during exponential-phase cellular growth through either reactive oxygen species (ROS)-dependent or ROS-independent pathways. Here, we found that the stationary-phase sigma factor sigma(S) was responsible for the resistance to mazEF-mediated cell death during stationary growth phase. Deletion of rpoS, the gene encoding sigma(S) from the bacterial chromosome, permitted mazEF-mediated cell death during stationary growth phase.

引用

页码：3177 / 3182

页数：6

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