Copper-Catalyzed Three-Component Synthesis of 3-Aminopyrazoles and 4-Iminopyrimidines via β-Alkynyl-N-sulfonyl Ketenimine Intermediates

被引：39

作者：

Xing, Yanpeng ^{[1
]}

Cheng, Binyu ^{[1
]}

Wang, Jing ^{[1
]}

Lu, Ping ^{[1
]}

Wang, Yanguang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 18期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; CLICK-CHEMISTRY; IN-SITU; MULTICOMPONENT REACTION; TERMINAL ALKYNES; FACILE ACCESS; AZIDE; PYRAZOLES; CYCLOADDITIONS; ISOMERIZATION;

D O I：

10.1021/ol502302w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Aminopyrazoles and 4-iminopyrimidines were efficiently prepared via copper-catalyzed three-component reactions of butadiynes, sulfonylazides, and hydrazides or imidamides. The reactions were regioselectively approached via the formation of a beta-alkynyl-N-sulfonyl ketenimine intermediate which represented a new and effective 1,3-dielectrophilic equivalent in organic synthesis.

引用

页码：4814 / 4817

页数：4

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