Ischemic preconditioning decreases intracellular zinc accumulation induced by oxygen-glucose deprivation in gerbil hippocampal CA1 neurons

被引：5

作者：

Miyawaki, T ^{[1
]}

Yokota, H

Oguro, K

Kato, K

Shimazaki, K

机构：

[1] Jichi Med Sch, Dept Neurol Surg, Minami Kawachi, Tochigi 3290498, Japan

[2] Haga Red Cross Hosp, Moka City, Tochigi 3214306, Japan

[3] Jichi Med Sch, Dept Physiol, Minami Kawachi, Tochigi 3290498, Japan

[4] Nippon Med Coll, Dept Internal Med 2, Sendagi, Tokyo 1138602, Japan

来源：

NEUROSCIENCE LETTERS | 2004年 / 362卷 / 03期

关键词：

zinc calcium; ischemic preconditioning; tolerance; Zn2+; imaging; hippocampal slice; gerbil;

D O I：

10.1016/j.neulet.2004.03.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In normal gerbils, intracellular zinc ions ([Zn2+](i)) and calcium ions ([Ca2+](i)) accumulate in hippocampal CA1 neurons after global ischemia. We examined whether ischemic preconditioning modifies these changes in gerbil hippocampal slices. In normal slices, large increases in [Zn2+](i) and [Ca2+](i) were observed in the stratum radiatum of the CA1 area after oxygen-glucose deprivation. In preconditioned slices, there were significantly decreased peak levels of [Zn2+](i) and [Ca2+](i) in CA1. However, there were no differences in the peak levels of these ions in CA3 and dentate gyrus. These results suggest that modified [Zn2+](i) and [Ca2+](i) accumulation after an ischemic insult might be important for the mechanisms of ischemic tolerance induced by preconditioning. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：216 / 219

页数：4

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