Prebiotic Phosphate Ester Syntheses in a Deep Eutectic Solvent

被引：50
作者：
Gull, Maheen [1 ]
Zhou, Manshui [2 ]
Fernandez, Facundo M. [2 ]
Pasek, Matthew A. [1 ]
机构：
[1] Univ S Florida, Sch Geosci, Tampa, FL 33620 USA
[2] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
来源：
JOURNAL OF MOLECULAR EVOLUTION | 2014年 / 78卷 / 02期
关键词：
Prebiotic synthesis; Phosphorylation; Origin of life; Deep eutectic solvents; Phosphate esters; PHOSPHORYLATION; PHOSPHORUS; ORIGIN; STRUVITE; ACID;
D O I：
10.1007/s00239-013-9605-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report a route to synthesize a wide range of organophosphates of biological significance in a deep eutectic solvent (2: 1 urea and choline chloride), utilizing various orthophosphate sources. Heating an organic alcohol in the solvent along with a soluble phosphorus source yields phosphorus esters of choline as well as that of the added organic in yields between 15 to 99 %. In addition, phosphite analogs of biological phosphates and peptides were also formed by the simple mixing of reagents and heating at 60-70 degrees C in the deep eutectic solvent. The presented dehydration reactions are relevant to prebiotic and green chemistry in alternative solvents.
引用
收藏
页码：109 / 117
页数：9
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