Cajaninstilbene acid analogues as novel quorum sensing and biofilm inhibitors of Pseudomonas aeruginosa

被引：11

作者：

Huang, Zhi-Xing ^{[1
]}

Yu, Jia-Hui ^{[1
]}

Xu, Xing-Jun ^{[1
]}

Xu, Xiao-Fang ^{[1
]}

Zeng, Ting ^{[1
]}

Lin, Jing ^{[1
]}

Chen, Wei-Min ^{[1
]}

机构：

[1] Jinan Univ, Coll Pharm, Guangzhou 510632, Peoples R China

来源：

MICROBIAL PATHOGENESIS | 2020年 / 148卷

基金：

中国国家自然科学基金;

关键词：

Cajaninstilbene acid; Anti-Biofilm; Quorum sensing regulator; Pseudomonas aeruginosa; BACTERIAL BIOFILMS; MECHANISMS; VIRULENCE; RESISTANCE; GENE; INTEGRATION; ANTIBIOTICS; ELASTASE; SYSTEMS; VECTORS;

D O I：

10.1016/j.micpath.2020.104414

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Biofilm formation and virulence factor secretion in opportunistic pathogen Pseudomonas aeruginosa are essential for establishment of chronic and recurrent infection, which are regulated by quorum sensing (QS) system. In this study, a set of cajaninstilbene acid analogues were designed and synthesized, and their abilities to inhibit QS and biofilm formation were investigated. Among all the compounds, compounds 3g, 3m and 3o showed potent antibiofilm activity, especially 3o exhibited promising biofilm inhibitory activity with biofilm inhibition ratio of 49.50 +/- 1.35% at 50 mu M. Three lacZ reporter strains were constructed to identify the effects of compound 3o on different QS systems. Compound 3o showed the suppression on the expression of lasB-lacZ and pqsA-lacZ as well as on the production of their corresponding virulence factors. Therefore, compound 3o is expected to be generated as a lead compound with inhibition of biofilm formation and QS of Pseudomonas aeruginosa.

引用

页数：9

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