Axon Guidance Molecules Implicated in Early-Onset Obesity

被引：5

作者：

Zeltser, Lori M. ^{[1
,2
]}

机构：

[1] Columbia Univ, Naomi Berrie Diabet Ctr, New York, NY 10027 USA

[2] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10027 USA

来源：

TRENDS IN NEUROSCIENCES | 2019年 / 42卷 / 07期

关键词：

HYPOTHALAMUS;

D O I：

10.1016/j.tins.2019.03.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Maternal nutritional status and the early growth rates of offspring influence the development of the melanocortin system and later susceptibility to metabolic dysregulation, but it is difficult to assess causality. A recent study by van der Klaauw et al. (Cell 2019;176:729-742) provides direct evidence that disrupting systems regulating neuronal circuit formation leads to early-onset obesity in zebrafish, mouse, and humans.

引用

页码：439 / 440

页数：2

共 10 条

[1] A molecular census of arcuate hypothalamus and median eminence cell types [J].

Campbell, John N. ;

Macosko, Evan Z. ;

Fenselau, Henning ;

Pers, Tune H. ;

Lyubetskaya, Anna ;

Tenen, Danielle ;

Goldman, Melissa ;

Verstegen, Anne M. J. ;

Resch, Jon M. ;

McCarroll, Steven A. ;

Rosen, Evan D. ;

Lowell, Bradford B. ;

Tsai, Linus T. .

NATURE NEUROSCIENCE, 2017, 20 (03) :484-496

[2] Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome [J].

Cariboni, Anna ;

Andre, Valentina ;

Chauvet, Sophie ;

Cassatella, Daniele ;

Davidson, Kathryn ;

Caramello, Alessia ;

Fantin, Alessandro ;

Bouloux, Pierre ;

Mann, Fanny ;

Ruhrberg, Christiana .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (06) :2413-2428

[3] Anatomy and regulation of the central melanocortin system [J].

Cone, RD .

NATURE NEUROSCIENCE, 2005, 8 (05) :571-578

[4] Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene [J].

Farooqi, IS ;

Keogh, JM ;

Yeo, GSH ;

Lank, EJ ;

Cheetham, T ;

O'Rahilly, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (12) :1085-1095

[5] Getting neural circuits into shape with semaphorins [J].

Pasterkamp, R. Jeroen .

NATURE REVIEWS NEUROSCIENCE, 2012, 13 (09) :605-618

[6] MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus [J].

Shah, Bhavik P. ;

Vong, Linh ;

Olson, David P. ;

Koda, Shuichi ;

Krashes, Michael J. ;

Ye, Chianping ;

Yang, Zongfang ;

Fuller, Patrick M. ;

Elmquist, Joel K. ;

Lowell, Bradford B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (36) :13193-13198

[7] Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index [J].

Speliotes, Elizabeth K. ;

Willer, Cristen J. ;

Berndt, Sonja I. ;

Monda, Keri L. ;

Thorleifsson, Gudmar ;

Jackson, Anne U. ;

Allen, Hana Lango ;

Lindgren, Cecilia M. ;

Luan, Jian'an ;

Maegi, Reedik ;

Randall, Joshua C. ;

Vedantam, Sailaja ;

Winkler, Thomas W. ;

Qi, Lu ;

Workalemahu, Tsegaselassie ;

Heid, Iris M. ;

Steinthorsdottir, Valgerdur ;

Stringham, Heather M. ;

Weedon, Michael N. ;

Wheeler, Eleanor ;

Wood, Andrew R. ;

Ferreira, Teresa ;

Weyant, Robert J. ;

Segre, Ayellet V. ;

Estrada, Karol ;

Liang, Liming ;

Nemesh, James ;

Park, Ju-Hyun ;

Gustafsson, Stefan ;

Kilpelaenen, Tuomas O. ;

Yang, Jian ;

Bouatia-Naji, Nabila ;

Esko, Tonu ;

Feitosa, Mary F. ;

Kutalik, Zoltan ;

Mangino, Massimo ;

Raychaudhuri, Soumya ;

Scherag, Andre ;

Smith, Albert Vernon ;

Welch, Ryan ;

Zhao, Jing Hua ;

Aben, Katja K. ;

Absher, Devin M. ;

Amin, Najaf ;

Dixon, Anna L. ;

Fisher, Eva ;

Glazer, Nicole L. ;

Goddard, Michael E. ;

Heard-Costa, Nancy L. ;

Hoesel, Volker .

NATURE GENETICS, 2010, 42 (11) :937-U53

[8] Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance [J].

van der Klaauw, Agatha A. ;

Croizier, Sophie ;

de Oliveira, Edson Mendes ;

Stadler, Lukas K. J. ;

Park, Soyoung ;

Kong, Youxin ;

Banton, Matthew C. ;

Tandon, Panna ;

Hendricks, Audrey E. ;

Keogh, Julia M. ;

Riley, Susanna E. ;

Papadia, Sofia ;

Henning, Elana ;

Bounds, Rebecca ;

Bochukova, Elena G. ;

Mistry, Vanisha ;

O'Rahilly, Stephen ;

Simerly, Richard B. ;

Minchin, James E. N. ;

Barroso, Ines ;

Jones, E. Yvonne ;

Bouret, Sebastien G. ;

Farooqi, I. Sadaf .

CELL, 2019, 176 (04) :729-+

[9] SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development [J].

Young, Jacques ;

Metay, Corinne ;

Bouligand, Jerome ;

Tou, Bassim ;

Francou, Bruno ;

Maione, Luigi ;

Tosca, Lucie ;

Sarfati, Julie ;

Brioude, Frederic ;

Esteva, Blandine ;

Briand-Suleau, Audrey ;

Brisset, Sophie ;

Goossens, Michel ;

Tachdjian, Gerard ;

Guiochon-Mantel, Anne .

HUMAN REPRODUCTION, 2012, 27 (05) :1460-1465

[10] Feeding circuit development and early-life influences on future feeding behaviour [J].

Zeltser, Lori M. .

NATURE REVIEWS NEUROSCIENCE, 2018, 19 (05) :302-316

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