THE CONCISE GUIDE TO PHARMACOLOGY 2013/14: ION CHANNELS

被引:222
作者
Alexander, Stephen P. H. [1 ]
Benson, Helen E. [2 ]
Faccenda, Elena [2 ]
Pawson, Adam J. [2 ]
Sharman, Joanna L. [2 ]
Catterall, William A. [3 ]
Spedding, Michael [4 ]
Peters, John A. [5 ]
Harmar, Anthony J. [2 ]
机构
[1] Univ Nottingham, Sch Med, Sch Life Sci, Nottingham NG7 2UH, England
[2] Univ Edinburgh, Univ BHF Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Midlothian, Scotland
[3] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA
[4] Spedding Res Solut SARL, F-78110 Le Vesinet, France
[5] Univ Dundee, Ninewells Hosp & Med Sch, Med Educ Inst, Div Neurosci, Dundee DD1 9SY, Scotland
基金
英国惠康基金;
关键词
UNION-OF-PHARMACOLOGY; EPITHELIAL SODIUM-CHANNEL; GATED PROTON CHANNEL; CELL-VOLUME REGULATION; CONDUCTANCE ANION CHANNEL; POTENTIAL CATION CHANNELS; CLC CHLORIDE CHANNELS; SMOOTH-MUSCLE-CELLS; INTERNATIONAL-UNION; NA+ CHANNEL;
D O I
10.1111/bph.12447
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley. com/doi/10.1111/bph.12444/full. Ion channels are one of the seven major pharmacological targets into which the Guide is divided, with the others being G protein-coupled receptors, ligand-gated ion channels, catalytic receptors, nuclear hormone receptors, transporters and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. A new landscape format has easy to use tables comparing related targets. It is a condensed version of material contemporary to late 2013, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in previous Guides to Receptors and Channels. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and the Guide to Receptors and Channels, providing a permanent, citable, point-in-time record that will survive database updates. Copyright © 2013 The British Pharmacological Society.
引用
收藏
页码:1607 / 1651
页数:45
相关论文
共 380 条
  • [1] Physiology and pathophysiology of canonical transient receptor potential channels
    Abramowitz, Joel
    Birnbaumer, Lutz
    [J]. FASEB JOURNAL, 2009, 23 (02) : 297 - 328
  • [2] Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels
    Accardi, A
    Miller, C
    [J]. NATURE, 2004, 427 (6977) : 803 - 807
  • [3] CLC channels and transporters: Proteins with borderline personalities
    Accardi, Alessio
    Picollo, Alessandra
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2010, 1798 (08): : 1457 - 1464
  • [4] A new member of the acid-sensing ion channel family
    Akopian, AN
    Chen, CC
    Ding, YN
    Cesare, P
    Wood, JN
    [J]. NEUROREPORT, 2000, 11 (10) : 2217 - 2222
  • [5] Anion Channels: Regulation of CIC-3 by an Orphan Second Messenger
    Alekov, Alexi K.
    Fahlke, Christoph
    [J]. CURRENT BIOLOGY, 2008, 18 (22) : R1061 - R1064
  • [6] Channel-like slippage modes in the human anion/proton exchanger ClC-4
    Alekov, Alexi K.
    Fahlke, Christoph
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 2009, 133 (05) : 485 - 496
  • [7] CFTR (ABCC7) is a hydrolyzable-ligand-gated channel
    Aleksandrov, Andrei A.
    Aleksandrov, Luba A.
    Riordan, John R.
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2007, 453 (05): : 693 - 702
  • [8] Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node
    Altomare, C
    Terragni, B
    Brioschi, C
    Milanesi, R
    Pagliuca, C
    Viscomi, C
    Moroni, A
    Baruscotti, M
    DiFrancesco, D
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2003, 549 (02): : 347 - 359
  • [9] Organization and function of TRPC channelosomes
    Ambudkar, Indu S.
    Ong, Hwei Ling
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2007, 455 (02): : 187 - 200
  • [10] TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH
    Andersson, DA
    Chase, HWN
    Bevan, S
    [J]. JOURNAL OF NEUROSCIENCE, 2004, 24 (23) : 5364 - 5369