Hepatic expression of the apoptosis signal-regulating kinase 1 (ASK1) marker, phosphorylated-P38 (p-P38), correlates with fibrosis stage in patients with NAFLD

被引：0
|
作者：
Huntzicker, Erik G. [1 ]
Goodman, Zachary D. [2 ]
Loomba, Rohit [3 ]
Charlton, Michael R. [4 ]
Newstrom, David [1 ]
Yen, Elizabeth H. [1 ]
Schall, Raul E. Aguilar [1 ]
Subramanian, Mani [1 ]
McHutchison, John G. [1 ]
Karnik, Satyajit [1 ]
Myers, Robert P. [1 ]
French, Dorothy [1 ]
机构：
[1] Gilead Sci Inc, Foster City, CA 94404 USA
[2] Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA USA
[3] Univ Calif San Diego, San Diego, CA 92103 USA
[4] Intermt Med Ctr, Murray, UT USA
来源：
HEPATOLOGY | 2015年 / 62卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
2149
引用
收藏
页码：1254A / 1254A
页数：1
相关论文
共 50 条
  • [41] Peroxiredoxin 1 has an anti-apoptotic role via apoptosis signal-regulating kinase 1 and p38 activation in mouse models with oral precancerous lesions
    Zhang, Jianfei
    Jing, Xinying
    Niu, Wenwen
    Zhang, Min
    Ge, Lihua
    Miao, Congcong
    Tang, Xiaofei
    ONCOLOGY LETTERS, 2016, 12 (01) : 413 - 420
  • [42] Microcystin-LR induces ovarian injury and apoptosis in mice via activating apoptosis signal-regulating kinase 1-mediated P38/JNK pathway
    Du, Xingde
    Liu, Haohao
    Liu, Xiaohui
    Chen, Xinghai
    Yuan, Le
    Ma, Ya
    Huang, Hui
    Wang, Yueqin
    Wang, Rui
    Zhang, Shiyu
    Tian, Zhihui
    Shi, Linjia
    Zhang, Huizhen
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 213
  • [43] Apoptosis signal-regulating kinase 1 (ASK1) and HIF-1α protein are essential factors for nitric oxide-dependent accumulation of p53 in THP-1 human myeloid macrophages
    Mohammad Jawahir
    Sally A. Nicholas
    Karen Coughlan
    Vadim V. Sumbayev
    Apoptosis, 2008, 13 : 1410 - 1416
  • [44] Apoptosis signal-regulating kinase 1 (ASK1) and HIF-1α protein are essential factors for nitric oxide-dependent accumulation of p53 in THP-1 human myeloid macrophages
    Jawahir, Mohammad
    Nicholas, Sally A.
    Coughlan, Karen
    Sumbayev, Vadim V.
    APOPTOSIS, 2008, 13 (12) : 1410 - 1416
  • [45] Upregulation of endothelial plasminogen activator inhibitor-1 (PAI-1) expression by high glucose through activation of apoptosis signal-regulating kinase 1 (ASK1)
    Yokoi, T
    Fukuo, K
    Ichijo, H
    Suzuki, T
    Yasuda, O
    Ogihara, T
    CIRCULATION, 2003, 108 (17) : 173 - 173
  • [46] Pharmacological inhibition of apoptosis signal-regulating kinase 1 (ASK1) in a murine model of NASH with pre-existing disease blocks fibrosis, steatosis, and insulin resistance
    Karnik, Satyajit
    Charlton, Michael
    Popov, Yury
    Goodman, Zachary D.
    Nash, Michelle
    Sulfab, Maisoun
    Barry, Vivian
    Huntzicker, Erik G.
    French, Dorothy
    Li, Kelvin
    Decaris, Martin
    Emson, Claire
    Turner, Scott M.
    Breckenridge, David
    Tumas, Daniel
    HEPATOLOGY, 2014, 60 : 570A - 570A
  • [47] SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway
    Shen, Jian
    Lai, Wenjia
    Li, Zeyang
    Zhu, Wenyuan
    Bai, Xue
    Yang, Zihao
    Wang, Qingsong
    Ji, Jianguo
    INFLAMMATION RESEARCH, 2024, 73 (09) : 1547 - 1564
  • [48] Tumor necrosis factor α-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation
    Li, XH
    Zhang, R
    Luo, DH
    Park, SJ
    Wang, Q
    Kim, Y
    Min, W
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (15) : 15061 - 15070
  • [49] Macrophage Migration Inhibitory Factor: A Novel Inhibitor of Apoptosis Signal-Regulating Kinase 1-p38-Xanthine Oxidoreductase-Dependent Cigarette Smoke-Induced Apoptosis
    Fallica, Jonathan
    Varela, Lidenys
    Johnston, Laura
    Kim, Bo
    Serebreni, Leonid
    Wang, Lan
    Damarla, Mahendra
    Kolb, Todd M.
    Hassoun, Paul M.
    Damico, Rachel
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2016, 54 (04) : 504 - 514
  • [50] ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney
    Ma, Frank Y.
    Tesch, Greg H.
    Nikolic-Paterson, David J.
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2014, 307 (11) : F1263 - F1273
12345