Hepatic expression of the apoptosis signal-regulating kinase 1 (ASK1) marker, phosphorylated-P38 (p-P38), correlates with fibrosis stage in patients with NAFLD

被引:0
|
作者
Huntzicker, Erik G. [1 ]
Goodman, Zachary D. [2 ]
Loomba, Rohit [3 ]
Charlton, Michael R. [4 ]
Newstrom, David [1 ]
Yen, Elizabeth H. [1 ]
Schall, Raul E. Aguilar [1 ]
Subramanian, Mani [1 ]
McHutchison, John G. [1 ]
Karnik, Satyajit [1 ]
Myers, Robert P. [1 ]
French, Dorothy [1 ]
机构
[1] Gilead Sci Inc, Foster City, CA 94404 USA
[2] Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA USA
[3] Univ Calif San Diego, San Diego, CA 92103 USA
[4] Intermt Med Ctr, Murray, UT USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
2149
引用
收藏
页码:1254A / 1254A
页数:1
相关论文
共 50 条
  • [1] Expression of matrix metalloproteinase 9 (MMP9) and the apoptosis signal-regulating kinase 1 (ASK1) pathway activation marker, phospho-P38 (p-P38), in primary sclerosing cholangitis (PSC)
    French, Dorothy
    Goodman, Zachary D.
    Huntzicker, Erik G.
    Newstrom, David
    Karnik, Satyajit
    Smith, Victoria
    Schall, Raul E. Aguilar
    Kanwar, Bittoo
    Subramanian, Mani
    McHutchison, John G.
    Muir, Andrew J.
    Myers, Robert P.
    HEPATOLOGY, 2015, 62 : 523A - 524A
  • [2] APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) ACTIVATES p38 MAPK SIGNALLING AND INDUCES INFLAMMATORY GLOMERULAR INJURY
    Amos, L. A.
    Han, Y.
    Breckenridge, D. G.
    Nikolic-Paterson, D. J.
    NEPHROLOGY, 2014, 19 : 27 - 27
  • [3] c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade
    Desbiens, KM
    Deschesnes, RG
    Labrie, MM
    Desfossés, Y
    Lambert, H
    Landry, J
    Bellmann, K
    BIOCHEMICAL JOURNAL, 2003, 372 : 631 - 641
  • [4] Apoptosis-signal regulating kinase 1 (ASK1) and p38 MAP kinase execute mycobacteria-induced macrophage apoptosis
    Basu, J
    Kundu, M
    FASEB JOURNAL, 2004, 18 (08): : C8 - C8
  • [5] APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) PROMOTES RENAL FIBROSIS AND APOPTOSIS IN THE OBSTRUCTED KIDNEY
    Ma, F. Y.
    Breckenridge, D.
    Nikolic-Paterson, D.
    NEPHROLOGY, 2013, 18 : 35 - 35
  • [6] Role of apoptosis signal-regulating kinase-1 (ASK1) in the development of pulmonary fibrosis
    Antoine, Julie
    Mohammadi, Azam
    Hadzic, Stefan
    Henneke, Ingrid
    Mahavadi, Poornima
    Krauss, Ekaterina
    Ruppert, Clemens
    Seeger, Werner
    Guenther, Andreas
    Korfei, Martina
    Korfei, Martina
    EUROPEAN RESPIRATORY JOURNAL, 2023, 62
  • [7] trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway
    Hirata, Yusuke
    Takahashi, Miki
    Kudoh, Yuki
    Kano, Kuniyuki
    Kawana, Hiroki
    Makide, Kumiko
    Shinoda, Yasuharu
    Yabuki, Yasushi
    Fukunaga, Kohji
    Aoki, Junken
    Noguchi, Takuya
    Matsuzawa, Atsushi
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (20) : 8174 - 8185
  • [8] Apoptosis Signal Regulating Kinase-1 (ASK1) Differentially Activates p38-and JNK-Mediated Inflammasome Pathways
    Immanuel, C. N.
    Teng, B.
    Dong, B.
    Tatum, J.
    Gordon, E.
    Luellen, C.
    Schwingshackl, A.
    Fitzpatrick, E. A.
    Cormier, S.
    Waters, C. M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199
  • [9] APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) PROMOTES RENAL FIBROSIS AND APOPTOSIS IN THE MOUSE OBSTRUCTED KIDNEY
    Ma, F. Y.
    Tesch, G. H.
    Nikolic-Paterson, D. J.
    NEPHROLOGY, 2014, 19 : 54 - 55
  • [10] Treatment with selonsertib, an inhibitor of apoptosis signal-regulating kinase 1, hepatic phospho-p38 expression and markers of hepatocellular apoptosis and necrosis in patients with nonalcoholic steatohepatitis
    Diehl, A. M.
    French, D.
    Xu, R.
    Loomba, R.
    Lawitz, E.
    Freilich, B.
    Shiffman, M. L.
    Chalasani, N.
    Hameed, B.
    Caldwell, S.
    Rinella, M.
    Peach, M.
    Huntzicker, E.
    Turner, S.
    Sullivan, T.
    Chen, G.
    Djedjos, C. S.
    Myers, R. P.
    Subramanian, G. M.
    Goodman, Z.
    Sirlin, C.
    Charlton, M.
    Afdhal, N. H.
    JOURNAL OF HEPATOLOGY, 2017, 66 (01) : S51 - S52