Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties

Polysaccharides from plants and fungi are considered nowadays as powerful pharmacological tools with a great therapeutic potential. In the meantime, efforts have been addressed to set up effective chemical modifications of naturally occurring polysaccharides to improve their biological effects as well as to positively modify some key parameters like solubility, bioavailability, pharmacokinetic, and similar. To this concern much attention has been focused during the last decade to the selenylation of natural polysaccharides from plants, algae, and fungi, the use of which is already encoded in ethnomedical traditions. The aim of this review article is to provide a detailed survey of the in so far reported literature data and a deeper knowledge about the state of the art on the chemical and pharmacological properties of selenylated polysaccharides of plant, algal, and fungal origin in terms of anti-oxidant, anti-cancer, anti-diabetic, and immunomodulatory activities. In all cases, literature data revealed that selenylation greatly improved such properties respect to the parent polysaccharides, indicating that selenylation is a valid, alternative, and effective chemical modification of naturally occurring carbohydrates.