Relationship between respiration, end-tidal CO2, and BOLD signals in resting-state fMRI

被引:241
作者
Chang, Catie [1 ]
Glover, Gary H.
机构
[1] Stanford Univ, Dept Elect Engn, Lucas MRI S Ctr, Stanford, CA 94305 USA
关键词
fMRI; Physiological noise; Respiration; End-tidal CO2; End-tidal O-2; Resting state; BOLD signal; Hemodynamic latency; HUMAN BRAIN; SENSORY STIMULATION; RESPONSE FUNCTION; CARBON-DIOXIDE; FUNCTIONAL MRI; HEART-RATE; FLUCTUATIONS; HUMANS; PCO2; LOCALIZATION;
D O I
10.1016/j.neuroimage.2009.04.048
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A significant component of BOLD fMRI physiological noise is caused by variations in the depth and rate of respiration. It has previously been demonstrated that a breath-to-breath metric of respiratory variation (respiratory volume per time; RVT), computed from pneumatic belt measurements of chest expansion, has a strong linear relationship with resting-state BOLD signals across the brain. RVT is believed to capture breathing-induced changes in arterial CO2, Which is a cerebral vasodilator; indeed, separate studies have found that spontaneous fluctuations in end-tidal CO2 (PETCO2) are correlated with BOLD signal time series. The present study quantifies the degree to which RVT and PETCO2 measurements relate to one another and explain common aspects of the resting-state BOLD signal. It is found that RVT (particularly when convolved with a particular impulse response, the "respiration response function") is highly correlated with PETCO2, and that both explain remarkably similar spatial and temporal BOLD signal variance across the brain. In addition, end-tidal O-2 is shown to be largely redundant with PETCO2. Finally, the latency at which PETCO2 and respiration belt measures are correlated with the time series of individual voxels is found to vary across the brain and may reveal properties of intrinsic vascular response delays. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:1381 / 1393
页数:13
相关论文
共 44 条
[1]  
Bandettini PA, 1997, NMR BIOMED, V10, P197, DOI 10.1002/(SICI)1099-1492(199706/08)10:4/5<197::AID-NBM466>3.0.CO
[2]  
2-S
[3]   TIME COURSE EPI OF HUMAN BRAIN-FUNCTION DURING TASK ACTIVATION [J].
BANDETTINI, PA ;
WONG, EC ;
HINKS, RS ;
TIKOFSKY, RS ;
HYDE, JS .
MAGNETIC RESONANCE IN MEDICINE, 1992, 25 (02) :390-397
[4]  
BERNE RM, 1993, PHYSIOLOGY, V422, P599
[5]   An inexpensive, MRI compatible device to measure tidal volume from chest-wall circumference [J].
Binks, Andrew P. ;
Banzett, Robert B. ;
Duvivier, Claude .
PHYSIOLOGICAL MEASUREMENT, 2007, 28 (02) :149-159
[6]   The respiration response function: The temporal dynamics of fMRI signal fluctuations related to changes in respiration [J].
Birn, Rasmus M. ;
Smith, Monica A. ;
Jones, Tyler B. ;
Bandettini, Peter A. .
NEUROIMAGE, 2008, 40 (02) :644-654
[7]   Separating respiratory-variation-related neuronal-activity-related fluctuations in fluctuations from fMRI [J].
Birn, RM ;
Diamond, JB ;
Smith, MA ;
Bandettini, PA .
NEUROIMAGE, 2006, 31 (04) :1536-1548
[8]  
Biswal B., 1993, Proc. S.M.R.M., P722
[9]   Mapping and correction of vascular hemodynamic latency in the BOLD signal [J].
Chang, Catie ;
Thomason, Moriah E. ;
Glover, Gary H. .
NEUROIMAGE, 2008, 43 (01) :90-102
[10]   Influence of heart rate on the BOLD signal: The cardiac response function [J].
Chang, Catie ;
Cunningham, John P. ;
Glover, Gary H. .
NEUROIMAGE, 2009, 44 (03) :857-869