Mechanisms of protein folding: Molecular chaperones and their application in biotechnology

被引:0
|
作者
Mogk, A
Mayer, MP
Deuerling, E
机构
[1] Zentrum Mol Biol, D-69120 Heidelberg, Germany
[2] Inst Biochem & Mol Biol, D-79104 Freiburg, Germany
关键词
aggregation; molecular chaperones; protein folding; recombinant protein production; trigger factor;
D O I
10.1002/1439-7633(20020902)3:9<807::AID-CBIC807>3.0.CO;2-A
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To fold or not to fold! Molecular chaperones are highly versatile molecules assisting a large variety of protein folding events during the entire lifespan of proteins. Knowledge about the network and functions of bacterial chaperones offers new prospects to improve the yield of properly folded recombinant proteins, perhaps boosting biotechnology.
引用
收藏
页码:807 / +
页数:9
相关论文
共 50 条
  • [41] Contribution of molecular chaperones to protein folding in the cytoplasm of prokaryotic and eukaryotic cells
    Naylor, DJ
    Hartl, FU
    FROM PROTEIN FOLDING TO NEW ENZYMES, 2001, 68 : 45 - 68
  • [42] Role of molecular chaperones in de novo protein folding and in misfolding disease
    Hartl, U
    PROTEIN SCIENCE, 2004, 13 : 67 - 67
  • [43] Protein Sculpting: Probing the Interplay between the Ribosome and Molecular Chaperones in Protein Folding in the Cell
    Addabbo, Rayna M.
    Dalphin, Matthew D.
    Liu, Yue
    Mecha, Miranda F.
    Cavagnero, Silvia
    BIOPHYSICAL JOURNAL, 2017, 112 (03) : 41A - 41A
  • [44] INTRAMOLECULAR CHAPERONES AND PROTEIN-FOLDING
    SHINDE, U
    INOUYE, M
    TRENDS IN BIOCHEMICAL SCIENCES, 1993, 18 (11) : 442 - 446
  • [45] Protein folding - Chaperones get Hip
    Ziegelhoffer, T
    Johnson, JL
    Craig, EA
    CURRENT BIOLOGY, 1996, 6 (03) : 272 - &
  • [46] Mimicking the action of folding chaperones in molecular dynamics simulations: Application to the refinement of homology-based protein structures
    Fan, H
    Mark, AE
    PROTEIN SCIENCE, 2004, 13 (04) : 992 - 999
  • [47] Insights into the molecular mechanisms of protein folding and misfolding
    Radford, SE
    PEPTIDES: FRONTIERS OF PEPTIDES SCIENCE, 1999, : 352 - 354
  • [48] POLYPEPTIDE INTERACTIONS WITH MOLECULAR CHAPERONES AND THEIR RELATIONSHIP TO IN-VIVO PROTEIN-FOLDING
    LANDRY, SJ
    GIERASCH, LM
    ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1994, 23 : 645 - 669
  • [49] Conformational plasticity of molecular chaperones involved in periplasmic and outer membrane protein folding
    Mas, Guillaume
    Hiller, Sebastian
    FEMS MICROBIOLOGY LETTERS, 2018, 365 (13)
  • [50] Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other
    Ebrahimi-Fakhari, Darius
    Saidi, Laiq-Jan
    Wahlster, Lara
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2013, 1