Mechanisms of protein folding: Molecular chaperones and their application in biotechnology

被引：1
作者：
Mogk, A
Mayer, MP
Deuerling, E
机构：
[1] Zentrum Mol Biol, D-69120 Heidelberg, Germany
[2] Inst Biochem & Mol Biol, D-79104 Freiburg, Germany
来源：
CHEMBIOCHEM | 2002年 / 3卷 / 09期
关键词：
aggregation; molecular chaperones; protein folding; recombinant protein production; trigger factor;
D O I：
10.1002/1439-7633(20020902)3:9<807::AID-CBIC807>3.0.CO;2-A
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To fold or not to fold! Molecular chaperones are highly versatile molecules assisting a large variety of protein folding events during the entire lifespan of proteins. Knowledge about the network and functions of bacterial chaperones offers new prospects to improve the yield of properly folded recombinant proteins, perhaps boosting biotechnology.
引用
收藏
页码：807 / +
页数：9
相关论文
共 38 条
  • [1] PURIFICATION AND CHARACTERIZATION OF RECOMBINANT HUMAN P50(CSK) PROTEIN-TYROSINE KINASE FROM AN ESCHERICHIA-COLI EXPRESSION SYSTEM OVERPRODUCING THE BACTERIAL CHAPERONES GROES AND GROEL
    AMREIN, KE
    TAKACS, B
    STIEGER, M
    MOLNOS, J
    FLINT, NA
    BURN, P
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (04) : 1048 - 1052
  • [2] PRINCIPLES THAT GOVERN FOLDING OF PROTEIN CHAINS
    ANFINSEN, CB
    [J]. SCIENCE, 1973, 181 (4096) : 223 - 230
  • [3] Getting newly synthesized proteins into shape
    Bukau, B
    Deuerling, E
    Pfund, C
    Craig, EA
    [J]. CELL, 2000, 101 (02) : 119 - 122
  • [4] The Hsp70 and Hsp60 chaperone machines
    Bukau, B
    Horwich, AL
    [J]. CELL, 1998, 92 (03) : 351 - 366
  • [5] Bukau B., 1999, MOL CHAPERONES FOLDI, P3
  • [6] GroEL/GroES-mediated folding of a protein too large to be encapsulated
    Chaudhuri, TK
    Farr, GW
    Fenton, WA
    Rospert, S
    Horwich, AL
    [J]. CELL, 2001, 107 (02) : 235 - 246
  • [7] INCREASED SOLUBILITY OF TRIMETHOPRIM-RESISTANT TYPE S1 DHFR FROM STAPHYLOCOCCUS-AUREUS IN ESCHERICHIA-COLI-CELLS OVERPRODUCING THE CHAPERONINS GROEL AND GROES
    DALE, GE
    SCHONFELD, HJ
    LANGEN, H
    STIEGER, M
    [J]. PROTEIN ENGINEERING, 1994, 7 (07): : 925 - 931
  • [8] Trigger factor and DnaK cooperate in folding of newly synthesized proteins
    Deuerling, E
    Schulze-Specking, A
    Tomoyasu, T
    Mogk, A
    Bukau, B
    [J]. NATURE, 1999, 400 (6745) : 693 - 696
  • [9] Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation
    Ehrnsperger, M
    Graber, S
    Gaestel, M
    Buchner, J
    [J]. EMBO JOURNAL, 1997, 16 (02) : 221 - 229
  • [10] In vivo observation of polypeptide flux through the bacterial chaperonin system
    Ewalt, KL
    Hendrick, JP
    Houry, WA
    Hartl, FU
    [J]. CELL, 1997, 90 (03) : 491 - 500
1234