Effect of Therapy With Rosuvastatin on Circulating Endothelial Progenitor Cells in Patients With Chronic Heart Failure

被引：0

作者：

Moiseeva, O. M. ^{[1
]}

Karelkina, E. V. ^{[1
]}

Moroshkin, V. S. ^{[1
]}

Selyutin, A. V. ^{[1
]}

Slyakhto, E. V. ^{[1
]}

机构：

[1] Russian Acad Med Sci, DO Otta Research Inst Obstet & Gynecol, St Petersburg, Russia

来源：

KARDIOLOGIYA | 2009年 / 49卷 / 05期

关键词：

circulating endothelial progenitor cells; heart failure; rosuvastatin; COA REDUCTASE INHIBITOR; STATIN THERAPY; ANGIOGENESIS; MORTALITY; ASSOCIATION; INCREASE;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We assessed effect of therapy with HMG-CoA reductase inhibitor rosuvastatin on the number of circulating hemopoietic stem CD34+, CD133+ cells in peripheral blood of patients with systolic left ventricular dysfunction of ischemic genesis. Number of circulating hemopoietic stem CD34+, CD133+ cells in patients with chronic heart failure did not differ from their number in control group, however we revealed tendency to increase of number of endothelial CD34+, CD133+, VEGFRA2+ progenitor cells. We confirmed presence of relationship between quantity of circulating stem and progenitor cells and traditional risk factors of cardiovascular events: age, excessive body mass, arterial hypertension, and intima-media thickness of common carotid arteries. Besides lipid lowering effect therapy with rosuvastatin was associated with lowering of C-reactive protein level and increase of number of circulating CD34+, CD133+ cells.

引用

页码：11 / 15

页数：5

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