Cu(II)-mediated one-pot alkoxide conjugate addition/radical cyclizations as a versatile method to highly functionalized tetrahydrofuran derivatives

被引：21

作者：

Jahn, U ^{[1
]}

Rudakov, D ^{[1
]}

机构：

[1] Tech Univ Braunschweig, Inst Organ Chem, D-38106 Braunschweig, Germany

来源：

SYNLETT | 2004年 / 07期

关键词：

cyclizations; electron transfer; Michael addition; radicals; tandem reactions;

D O I：

10.1055/s-2004-822930

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of highly functionalized 3-nitrotetrahydrofurans starting from allylic alcohols and nitroalkenes through an efficient CuCl2-mediated tandem anionic/radical process is reported. The one-pot reaction consists of oxa-Michael addition/SET/radical 5-exo-cyclization-ligand transfer. Functionalization of the THF ring is facile and provides diverse substituted derivatives.

引用

页码：1207 / 1210

页数：4

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