Study of the interaction between trypanocide 3-nitrobenzaldehyde guanyl hydrazone and bovine serum albumin by equilibrium dialysis and NMR

被引：4

作者：

Tinoco, LW ^{[1
]}

Figueroa-Villar, JD ^{[1
]}

机构：

[1] Inst Militar Engn, Dept Quim, BR-22290270 Rio De Janeiro, Brazil

来源：

SPECTROSCOPY LETTERS | 1999年 / 32卷 / 06期

关键词：

3-nitrobenzaldehyde guanyl hydrazone; equilibrium dialysis; NMR spin-lattice relaxation time;

D O I：

10.1080/00387019909350039

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Equilibrium dialysis and NMR spin-lattice relaxation time (T-1) studies of the interaction of the trypanocidal drug 3-nitrobenzaldehyde guanyl hydrazone (3NBGH) with bovine serum albumin (BSA) were used to show that this interaction is weak and nonspecific, making 3NBGH a potential agent for the prophylaxis of Trypanosoma cruzi infected blood.

引用

页码：941 / 951

页数：11

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