Triphase Interface Synthesis of Plasmonic Gold Bellflowers as Near-Infrared Light Mediated Acoustic and Thermal Theranostics

被引：191

作者：

Huang, Peng ^{[1
]}

Rong, Pengfei ^{[1
,2
,4
]}

Lin, Jing ^{[1
]}

Li, Wanwan ^{[1
]}

Yan, Xuefeng ^{[1
]}

Zhang, Molly Gu ^{[1
]}

Nie, Liming ^{[1
,3
]}

Niu, Gang ^{[1
]}

Lu, Jie ^{[1
]}

Wang, Wei

Chen, Xiaoyuan ^{[1
]}

机构：

[1] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA

[2] Cent S Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China

[3] Xiamen Univ, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, Sch Publ Hlth, Xiamen 361005, Peoples R China

[4] Cent S Univ, Xiangya Hosp 3, Dept Radiol, Changsha 410013, Hunan, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 23期

基金：

美国国家科学基金会;

关键词：

EARTH FLUORIDE NANOCRYSTALS; PHOTOTHERMAL THERAPY; MULTIFUNCTIONAL NANOPARTICLES; GRAPHENE OXIDE; ULTRASOUND; NANOCAGES; NANORODS; DELIVERY; AGENT; SIZE;

D O I：

10.1021/ja503115n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present a novel gold bellflower (GBF) platform with multiple-branched petals, prepared by a liquid-liquid-gas triphase interface system, for photoacoustic imaging (PAI)-guided photothermal therapy (PTT). Upon near-infrared (NIR) laser irradiation, the GBFs, with strong NIR absorption, showed very strong PA response and an ultrahigh photothermal conversion efficiency (eta, similar to 74% among the reported photothermal conversion agents. The excellent performance in PAI and PTT is mainly attributed to the unique features of the GBFs: (i) multiple-branched petals with an enhanced local electromagnetic field, (ii) long narrow gaps between adjacent petals that induce a strong plasmonic coupling effect, and (iii) a bell-shaped effectively amplify the acoustic signals during the acoustic propagation. Besides the notable PTT and an excellent PAI effect, the NIR-absorbing GBFs may also find applications in NIR light-triggered drug delivery, catalysis, surface enhanced Raman scattering, stealth, antireflection, IR sensors, telecommunications, and the like.

引用

页码：8307 / 8313

页数：7

共 71 条

[31] Multifunctional nanoparticles for multimodal imaging and theragnosis [J].