Triphase Interface Synthesis of Plasmonic Gold Bellflowers as Near-Infrared Light Mediated Acoustic and Thermal Theranostics

被引：187
作者：
Huang, Peng [1 ]
Rong, Pengfei [1 ,2 ,4 ]
Lin, Jing [1 ]
Li, Wanwan [1 ]
Yan, Xuefeng [1 ]
Zhang, Molly Gu [1 ]
Nie, Liming [1 ,3 ]
Niu, Gang [1 ]
Lu, Jie [1 ]
Wang, Wei
Chen, Xiaoyuan [1 ]
机构：
[1] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
[2] Cent S Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China
[3] Xiamen Univ, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, Sch Publ Hlth, Xiamen 361005, Peoples R China
[4] Cent S Univ, Xiangya Hosp 3, Dept Radiol, Changsha 410013, Hunan, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 23期
基金：
美国国家科学基金会;
关键词：
EARTH FLUORIDE NANOCRYSTALS; PHOTOTHERMAL THERAPY; MULTIFUNCTIONAL NANOPARTICLES; GRAPHENE OXIDE; ULTRASOUND; NANOCAGES; NANORODS; DELIVERY; AGENT; SIZE;
D O I：
10.1021/ja503115n
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We present a novel gold bellflower (GBF) platform with multiple-branched petals, prepared by a liquid-liquid-gas triphase interface system, for photoacoustic imaging (PAI)-guided photothermal therapy (PTT). Upon near-infrared (NIR) laser irradiation, the GBFs, with strong NIR absorption, showed very strong PA response and an ultrahigh photothermal conversion efficiency (eta, similar to 74% among the reported photothermal conversion agents. The excellent performance in PAI and PTT is mainly attributed to the unique features of the GBFs: (i) multiple-branched petals with an enhanced local electromagnetic field, (ii) long narrow gaps between adjacent petals that induce a strong plasmonic coupling effect, and (iii) a bell-shaped effectively amplify the acoustic signals during the acoustic propagation. Besides the notable PTT and an excellent PAI effect, the NIR-absorbing GBFs may also find applications in NIR light-triggered drug delivery, catalysis, surface enhanced Raman scattering, stealth, antireflection, IR sensors, telecommunications, and the like.
引用
收藏
页码：8307 / 8313
页数：7
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  • [21] A general strategy for metallic nanocrystals synthesis in organic medium
    Huang, Peng
    Lin, Jing
    Li, Zhiming
    Hu, Hengyao
    Wang, Kan
    Gao, Guo
    He, Rong
    Cui, Daxiang
    [J]. CHEMICAL COMMUNICATIONS, 2010, 46 (26) : 4800 - 4802
  • [22] Plasmonic photothermal therapy (PPTT) using gold nanoparticles
    Huang, Xiaohua
    Jain, Prashant K.
    El-Sayed, Ivan H.
    El-Sayed, Mostafa A.
    [J]. LASERS IN MEDICAL SCIENCE, 2008, 23 (03) : 217 - 228
  • [23] A Reexamination of Active and Passive Tumor Targeting by Using Rod-Shaped Gold Nanocrystals and Covalently Conjugated Peptide Ligands
    Huang, Xiaohua
    Peng, Xianghong
    Wang, Yiqing
    Wang, Yuxiang
    Shin, Dong M.
    El-Sayed, Mostafa A.
    Nie, Shuming
    [J]. ACS NANO, 2010, 4 (10) : 5887 - 5896
  • [24] Engineering multifunctional nanoparticles: all-in-one versus one-for-all
    Huynh, Elizabeth
    Zheng, Gang
    [J]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2013, 5 (03) : 250 - 265
  • [25] Porphyrin Shell Microbubbles with Intrinsic Ultrasound and Photoacoustic Properties
    Huynh, Elizabeth
    Lovell, Jonathan F.
    Helfield, Brandon L.
    Jeon, Mansik
    Kim, Chulhong
    Goertz, David E.
    Wilson, Brian C.
    Zheng, Gang
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (40) : 16464 - 16467
  • [26] Imaging and drug delivery using theranostic nanoparticles
    Janib, Siti M.
    Moses, Ara S.
    MacKay, J. Andrew
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (11) : 1052 - 1063
  • [27] In Vivo Photoacoustic Tomography of Chemicals: High-Resolution Functional and Molecular Optical Imaging at New Depths
    Kim, Chulhong
    Favazza, Christopher
    Wang, Lihong V.
    [J]. CHEMICAL REVIEWS, 2010, 110 (05) : 2756 - 2782
  • [28] Nanoshell-Enabled Photothermal Cancer Therapy: Impending Clinical Impact
    Lal, Surbhi
    Clare, Susan E.
    Halas, Naomi J.
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 2008, 41 (12) : 1842 - 1851
  • [29] Effect of intratumoral injection on the biodistribution and the therapeutic potential of HPMA copolymer-based drug delivery systems
    Lammers, Twan
    Peschke, Peter
    Kuehnlein, Rainer
    Subr, Vladimir
    Ulbrich, Karel
    Huber, Peter
    Hennink, Wim
    Storm, Gert
    [J]. NEOPLASIA, 2006, 8 (10): : 788 - 795
  • [30] Selective laser nano-thermolysis of human leukemia cells with microbubbles generated around clusters of gold nanoparticles
    Lapotko, Dmitri O.
    Lukianova, Ekaterina
    Oraevsky, Alexander A.
    [J]. LASERS IN SURGERY AND MEDICINE, 2006, 38 (06) : 631 - 642
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